BIBP 3226
- CAS No.
- 159013-54-4
- Chemical Name:
- BIBP 3226
- Synonyms
- BIBP 3226 trifluoroa;BIBP 3226 trifluoroacetate;BIBP3226 trifluoroacetate salt Diphenylacetyl-D-Arg-4-hydroxybenzylamide trifluoroacetate salt;(2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;Benzeneacetamide, N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-;N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamidetrifluoroacetate
- CBNumber:
- CB7497915
- Molecular Formula:
- C27H31N5O3
- Molecular Weight:
- 473.57
- MDL Number:
- MFCD00938562
- MOL File:
- 159013-54-4.mol
| Density | 1.24±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL |
| form | A solid |
| pka | 9.71±0.15(Predicted) |
| Water Solubility | H2O: 1mg/mL |
| FDA UNII | RG9766UGZ8 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BIBP 3226 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B174 | BIBP 3226 | 159013-54-4 | 5mg | $949 | 2022-05-15 | Buy |
| Tocris | 2707 | BIBP3226trifluoroacetate ≥98%(HPLC) | 159013-54-4 | 1 | $151 | 2021-12-16 | Buy |
| Tocris | 2707 | BIBP3226trifluoroacetate ≥98%(HPLC) | 159013-54-4 | 10 | $324 | 2021-12-16 | Buy |
| Usbiological | 254749 | BIBP 3226 trifluoroacetate | 159013-54-4 | 1mg | $389 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004663 | BIBP 3226 95.00% | 159013-54-4 | 1MG | $571.2 | 2021-12-16 | Buy |
BIBP 3226 Chemical Properties,Uses,Production
Uses
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2].
Biological Activity
Mixed non-peptide neuropeptide Y Y 1 (NPY Y 1 ) and neuropeptide FF (NPFF) receptor antagonist (K i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y 1 , hNPFF 2 , rNPFF, rNPY Y 2 , rNPY Y 4 and rNPY Y 5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.
Biochem/physiol Actions
Selective non-peptide neuropeptide Y1 (NPY1) receptor antagonist.
in vivo
BIBP3226 (0.5, 5 μg; i.c.v.; male Wistar rats) induces an anxiogenic-like effect at the higher dose[1].
References
[1] Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. DOI:10.1038/sj.bjp.0704049
BIBP 3226 Preparation Products And Raw materials
Raw materials
Preparation Products
BIBP 3226 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5222 | 58 |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42957 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
