BP 897
- CAS No.
- 314776-92-6
- Chemical Name:
- BP 897
- Synonyms
- BP897/BP-897;BP 897 (hydrochloride);BP897 >98% (HPLC), solid;N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide;N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride;N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride;Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
- CBNumber:
- CB7503212
- Molecular Formula:
- C26H31N3O2
- Molecular Weight:
- 417.55
- MDL Number:
- MFCD04039996
- MOL File:
- 314776-92-6.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 10 mg/mL, soluble |
| form | solid |
| color | off-white |
| FDA UNII | 20PLE5W821 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BP 897 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B9308 | BP897 >98% (HPLC), solid | 314776-92-6 | 5mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 25831 | BP-897 | 314776-92-6 | 1mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 25831 | BP-897 | 314776-92-6 | 25mg | $246 | 2024-03-01 | Buy |
| Cayman Chemical | 25831 | BP-897 | 314776-92-6 | 5mg | $88 | 2024-03-01 | Buy |
| Cayman Chemical | 25831 | BP-897 | 314776-92-6 | 10mg | $132 | 2024-03-01 | Buy |
BP 897 Chemical Properties,Uses,Production
Description
BP-897 is a dopamine D3 receptor partial agonist. It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α1- and α2-adrenergic receptors (Kis = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT7 (Kis = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (Kis = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC50 = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D3 receptor antagonist nafadotride. It also acts as a dopamine D3 receptor antagonist, failing to increase [35S]GTPγS binding to CHO cell membranes expressing the recombinant human D3 receptor and inhibiting the effect of dopamine in the same assay (IC50 = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.
Biochem/physiol Actions
Partially selective D3 dopamine receptor agonist.
BP 897 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 3296 | 50 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-027-87342388 18086026008 | sales@kaymke.com | China | 3939 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |