Docosanoic Acid-d4
- CAS No.
- 1208430-53-8
- Chemical Name:
- Docosanoic Acid-d4
- Synonyms
- Docosanoic Acid-d4
- CBNumber:
- CB76197554
- Molecular Formula:
- C22H44O2
- Molecular Weight:
- 340.59
- MDL Number:
- MFCD05864276
- MOL File:
- 1208430-53-8.mol
Docosanoic Acid-d4 Chemical Properties,Uses,Production
Biological Activity
Docosanoic acid-d4 is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 μM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 μM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
References
1.Dean, L.L., and Sanders, T.H.Hexacosanoic acid and other very long-chain fatty acids in peanut seed oilPlant Genet. Resour.7(3)252-256(2009) 2.Sánchez-Machado, D.I., López-Cervantes, J., Nú?ez-Gastélum, J.A., et al.Effect of the refining process on Moringa oleifera seed oil qualityFood Chem.18753-57(2015) 3.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 4.Yonezawa, Y., Hada, T., Uryu, K., et al.Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerasesInt. J. Mol. Med.18(4)583-588(2006) 5.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approachRedox Biol.9296-305(2016)
Docosanoic Acid-d4 Preparation Products And Raw materials
Raw materials
Preparation Products
Docosanoic Acid-d4 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Reer Technology (Shanghai) Co., LTD | 021-64400900 15800436310 | bessey@reertech.com | China | 4113 | 58 |
Supplier | Advantage |
---|---|
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
Reer Technology (Shanghai) Co., LTD | 58 |