Glabridin
- CAS No.
- 59870-68-7
- Chemical Name:
- Glabridin
- Synonyms
- Q-100692;GLABRIDIN;LGB-GD 90;LGB-GD 40;KB-289522;LS-176045;Aids096010;glabridine;Aids-096010;Glabridin-RM
- CBNumber:
- CB7670448
- Molecular Formula:
- C20H20O4
- Molecular Weight:
- 324.37
- MDL Number:
- MFCD03427694
- MOL File:
- 59870-68-7.mol
- MSDS File:
- SDS
| Melting point | 154～155℃ |
|---|---|
| Boiling point | 518.6±50.0 °C(Predicted) |
| Density | 1.257±0.06 g/cm3(Predicted) |
| Flash point | 267℃ |
| storage temp. | room temp |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | 9.66±0.40(Predicted) |
| color | white to light brown |
| BRN | 7141956 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 |
| InChIKey | PMPYOYXFIHXBJI-ZDUSSCGKSA-N |
| SMILES | C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1 |
| LogP | 4.260 (est) |
| CAS DataBase Reference | 59870-68-7(CAS DataBase Reference) |
| FDA UNII | HOC5567T41 |
| UNSPSC Code | 85151701 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Glabridin price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G9548 | Glabridin ≥98% (HPLC), powder | 59870-68-7 | 5mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80463 | Glabridin phyproof? Reference Substance | 59870-68-7 | 10MG | $584 | 2024-03-01 | Buy |
| Sigma-Aldrich | 53633 | Glabridin analytical standard | 59870-68-7 | 10mg | $826 | 2022-05-15 | Buy |
| Cayman Chemical | 11843 | Glabridin ≥98% | 59870-68-7 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 11843 | Glabridin ≥98% | 59870-68-7 | 10mg | $89 | 2024-03-01 | Buy |
Glabridin Chemical Properties,Uses,Production
Chemical Properties
White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc.
Uses
Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.
Definition
ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.
benefits
Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant.
Biochem/physiol Actions
Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to posses varies biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9.
Mode of action
Glabridin[59870-68-7] is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolic process of the body, to avoid oxidative damage to oxidation-sensitive biological macromolecules (low-density lipoprotein LDL, DNA) and the cell wall, etc. by free radical oxidation. Thus, it can prevent certain pathological changes related to free radical oxidation, such as atherosclerosis, and cellular aging. In addition, Glabridin has some hypolipidemic and hypotensive effects.
References
Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel ?uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);
Glabridin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1169 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3005 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +86-15271838296; +8615271838296 | kyra@quanjinci.com | China | 1512 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 452 | 58 |
| Hangzhou Lin'an tianhong biotechnology co.,ltd. | +86-0571-58605786 +8613858113248 | admin@tianhongsw.com | China | 49 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12806 | 58 |
Related articles
- Glabridin: A Promising Compound in Cosmetic Chemistry
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- Jan 9，2025
- The antibacterial and skin-whitening property of Glabridin
- Glabridin, also knownas Licorice extract, is the main secondary metabolite of the rhizomes of?Glycyrrhiza glabra. This compoun....
- Oct 27，2023
View Lastest Price from Glabridin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Glabridin
59870-68-7
|
US $0.00-0.00 / g | 1KG | 10% 40% 90% 98% | 5000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-28 | Glabridin
59870-68-7
|
US $0.00-0.00 / kg | 1kg | 99.99% | 20 tons | Chongqing Soarwin Technology Co., Ltd | |
 |
2025-04-28 | Glabridin
59870-68-7
|
US $0.00-0.00 / g | 1g | 98% | 2000 | Changsha Staherb Natural Ingredients Co., Ltd. |