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AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE

CAS No.
167114-91-2
Chemical Name:
AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE
Synonyms
ALP;LYS-LYS-ALA-LEU-ARG-ARG-GLN-GLU-ALA-VAL-ASP-ALA-LEU;ILC;CCL27;ESKINE;Alk Phos;FLJ10774;Skinkine;CTACK HUMAN;DKFZp434C116
CBNumber:
CB7671283
Molecular Formula:
C64H116N22O19
Molecular Weight:
1497.74
MDL Number:
MFCD17215342
MOL File:
167114-91-2.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Properties

storage temp. -20°C
solubility H2O: soluble
form lyophilized powder
color white
Water Solubility Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

Hazard Codes  Xn,F
Risk Statements  20/21/22-36-11
Safety Statements  22-24/25-26-36/37-16
WGK Germany  3

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB3701239 Anti-Human IgG F(ab′)2, F(ab′)2 fragment, highly cross absorbed-Alkaline Phosphatase antibody produced in goat affinity isolated antibody, buffered aqueous solution 167114-91-2 500μg $306 2024-03-01 Buy
Sigma-Aldrich SAB3700469 Anti-HAMSTER IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 167114-91-2 500μg $276 2024-03-01 Buy
Sigma-Aldrich SAB3700461 Anti-Hamster IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat affinity isolated antibody, buffered aqueous solution 167114-91-2 500μl $309 2024-03-01 Buy
Sigma-Aldrich SAB3700401 Anti-Guinea Pig IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 167114-91-2 500μg $276 2024-03-01 Buy
Sigma-Aldrich SAB3700053 Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 167114-91-2 1mg $277 2024-03-01 Buy
Product number Packaging Price Buy
SAB3701239 500μg $306 Buy
SAB3700469 500μg $276 Buy
SAB3700461 500μl $309 Buy
SAB3700401 500μg $276 Buy
SAB3700053 1mg $277 Buy

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Chemical Properties,Uses,Production

Uses

Autocamtide-2-Related Inhibitory Peptide is a highly specific and potent inhibitor of CaMKII.

Uses

Autocamtide 2-related inhibitory peptide has been used:

  • To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
  • To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
  • To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Biological Activity

synthetic peptide aip (autocamtide-2-related inhibitory peptide) is a nonphosphorylatable analog of autocamtide-2, which was identified to be a highly specific and potent inhibitor of calmodulin-dependent protein kinase ii (cam-kinase ii, camkii). camkii is a serine/threonine-specific protein kinase, which is modulated by the ca2+/calmodulin.

Biochem/physiol Actions

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

in vitro

aip (1 mm) completely inhibited camkii activity, but did not affect camp-dependent protein kinase, calmodulin-dependent protein kinase iv and protein kinase c,. the inhibition was noncompetitive, and the action was caused by binding to the autophosphorylation site, which is distinc from that for the exogenous substrate. the ic50 for the autophosphorylation of cam ii is 100 nm [1].

in vivo

mice treated with aip by transgenic expression of aip, were protected from fructose-rich diet-induced arrhythmogenesis, spontaneous contractions and spontaneous ca2+ release events [2]. intra-nucleus accumbens (nac) injection of aip could dose-dependently increase the hwl (hindpaw withdrawal latency) to noxious thermal and mechanical stimulation in rats with mononeuropathy [3].

IC 50

40 nm for cam-kinase ii [1].

storage

Store at -20°C

References

[1] ishida a1, kameshita i, okuno s, kitani t, fujisawa h. a novel highly specific and potent inhibitor of calmodulin-dependent protein kinase ii. biochem biophys res commun. 1995 jul 26;212(3):806-12.
[2] sommese l, valverde ca, blanco p, castro mc, rueda ov, kaetzel m, dedman j, anderson me, mattiazzi a, palomeque j. ryanodine receptor phosphorylation by camkii promotes spontaneous ca(2+) release events in a rodent model of early stage diabetes: the arrhythmogenic substrate. int j cardiol. 2016 jan 1;202:394-406.
[3] bian h, yu lc. intra-nucleus accumbens administration of the calcium/calmodulin-dependent protein kinase ii inhibitor aip induced antinociception in rats with mononeuropathy. neurosci lett. 2015 jul 10;599:129-32.

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE Suppliers

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18751 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Cellmano Biotech Limited
0551-65326643 18156095617 info@cellmano.com China 999 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Qiuxian Baitai New Material Co., LTD
+8618330912755 sale2@hbyalin.com China 1658 58
BOC Sciences
16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech
0571-88211921 sales1@gotopbio.com CHINA 2609 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58

View Lastest Price from AUTOCAMTIDE-2-RELATED INHIBITORY PEPTIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Autocamtide-2-related inhibitory peptide pictures 2024-11-19 Autocamtide-2-related inhibitory peptide
167114-91-2
US $80.00-272.00 / mg 100% 10g TargetMol Chemicals Inc.
Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt pictures 2022-10-25 Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt
167114-91-2
US $10.00 / KG 1KG 99% Ex 20 tons Hebei Anda Technology Co., LTD
alp pictures 2021-12-16 alp
167114-91-2
US $470.00 / mg 1KG 98% 500ton/Month Qiuxian Baitai New Material Co., LTD
  • alp pictures
  • alp
    167114-91-2
  • US $470.00 / mg
  • 98%
  • Qiuxian Baitai New Material Co., LTD
Anti-Guinea Pig IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat Anti-Goat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-goat IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit Anti-goat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey Anti-Chicken IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Human IgM (Fc5μ)-Alkaline Phosphatase antibody produced in rabbit Anti-Human IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit Anti-Human IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Human IgG (Fc specific), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat Anti-Human IgG F(ab′)2, F(ab′)2 fragment, highly cross absorbed-Alkaline Phosphatase antibody produced in goat Anti-Mouse IgM (μ-chain specific), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in goat Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat Anti-Mouse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat Anti-Mouse IgG F(ab′)2, highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in chicken Anti-Rabbit IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in goat Anti-Rabbit IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Rabbit IgG (Fc specific)-Alkaline Phosphatase antibody produced in donkey Anti-Rabbit IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat Anti-Donkey IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit Anti-Ferret IgA (α-chain specific)-Alkaline Phosphatase antibody produced in goat Anti-Monkey IgA (α-chain specific)-Alkaline Phosphatase antibody produced in goat (ALA9)-AUTOCAMTIDE-2 ALS9 AUTOCAMTIDE 2 Anti-Rabbit IgG (H+L)-Alkaline Phosphatase antibody produced in donkey Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in chicken Anti-Mouse IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in goat Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in rabbit Anti-Mouse IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit Anti-Mouse IgG (H+L)-Alkaline Phosphatase antibody produced in sheep Anti-Mouse IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit Alk Phos Anti-Bovine IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit Anti-Chicken IgG (Fc specific)-Alkaline Phosphatase antibody produced in rabbit Anti-Chicken IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat Anti-Horse IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat Anti-Dog IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit Anti-Dog IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit Anti-Dog IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat Anti-Cat IgG (Fc specific)-Alkaline Phosphatase antibody produced in goat Anti-Cat IgG F(ab′)2-Alkaline Phosphatase antibody produced in goat Anti-Bovine IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit Anti-Ferret IgG (γ-chain specific)-Alkaline Phosphatase antibody produced in goat Anti-Ferret IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat Anti-Sheep IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit Anti-Sheep IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Sheep IgG F(ab′)2-Alkaline Phosphatase antibody produced in rabbit Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in goat Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in donkey Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in donkey Anti-Rat IgG (H+L), highly cross adsorbed-Alkaline Phosphatase antibody produced in goat Anti-Sheep IgG (Fc specific), highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit Anti-Rat IgM (μ-chain specific)-Alkaline Phosphatase antibody produced in rabbit Anti-Rat IgG (H+L), F(ab′)2 fragment, highly cross adsorbed-Alkaline Phosphatase antibody produced in rabbit Anti-Rat IgG (H+L), F(ab′)2 fragment-Alkaline Phosphatase antibody produced in rabbit Anti-Rat IgG (H+L)-Alkaline Phosphatase antibody produced in sheep