NAFRONYL
- CAS No.
- 31329-57-4
- Chemical Name:
- NAFRONYL
- Synonyms
- Tridus;Citoxid;Nafmnyl;Dubimax;Dusodril;NAFRONYL;Gevatran;Praxilene;Di-Actane;Naftidrofuryl
- CBNumber:
- CB7759257
- Molecular Formula:
- C24H33NO3
- Molecular Weight:
- 383.53
- MDL Number:
- MFCD00868290
- MOL File:
- 31329-57-4.mol
- MSDS File:
- SDS
| Boiling point | bp0.5 190° |
|---|---|
| Density | d431 1.0465 |
| refractive index | nD29 1.5513 |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 9.21±0.25(Predicted) |
| color | Colourless to Dark Yellow |
| CAS DataBase Reference | 31329-57-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 42H8PQ0NMJ |
| ATC code | C04AX21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 in mice (mg/kg): 365 orally (Bessin) |
NAFRONYL price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | N215000 | Nafronyl | 31329-57-4 | 5mg | $160 | 2021-12-16 | Buy |
| TRC | N215000 | Nafronyl | 31329-57-4 | 50mg | $1295 | 2021-12-16 | Buy |
| Chemenu | CM139840 | 2-(Diethylamino)ethyl3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate 95% | 31329-57-4 | 1g | $1870 | 2021-12-16 | Buy |
| Crysdot | CD31002289 | Nafronyl 95+% | 31329-57-4 | 1g | $1984 | 2021-12-16 | Buy |
| AHH | MT-56369 | Nafronyl 98% | 31329-57-4 | 0.5g | $910 | 2021-12-16 | Buy |
NAFRONYL Chemical Properties,Uses,Production
Originator
Dusodril,Roland,W. Germany,1968
Uses
Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.
Uses
Vasodilator.
Definition
ChEBI: 2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.
Manufacturing Process
30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are
heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams
(0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the
isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3.
Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with
a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity =
40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved
while being made tepid in 8 cc of acetone. The cooled solution has added
thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'-
tetrahydrofuryl isobutyrate, obtained according to the process described above
and dissolved in 10 cc of acetone. The solution is brought to boiling point for
15 minutes. After cooling to ambient temperature, it is placed in a
refrigerator. Crystallization occurs after 2 hours, the crystals which have
formed are separated by centrifuging, and after washing in hexane and drying
in vacuo 3.5 grams of white crystals are obtained. After being recrystallized
three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the
product is analytically pure and has a MP = 110° to 111°C (heating stage).
brand name
Praxilene (Lipha, S.A., France).
Therapeutic Function
Vasodilator
World Health Organization (WHO)
Naftidrofuryl is a vasoactive spasmolytic used to treat peripheral vascular disease. It also improves the oxygen utilization in tissues.
NAFRONYL Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
View Lastest Price from NAFRONYL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-24 | Naftidrofuryl
31329-57-4
|
US $1670.00-2180.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2019-12-31 | NAFRONYL
31329-57-4
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- Naftidrofuryl
31329-57-4
- US $1670.00-2180.00 / mg
- TargetMol Chemicals Inc.
-
- NAFRONYL
31329-57-4
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co
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