SONGORINE
- CAS No.
- Chemical Name:
- SONGORINE
- Synonyms
- SONGORINE
- CBNumber:
- CB7782282
- Molecular Formula:
- C22H31NO3
- Molecular Weight:
- 357.49
- MDL Number:
- MFCD04037233
- MOL File:
- Mol file
Melting point | 212°C (20l-3°C) |
---|---|
EWG's Food Scores | 1 |
FDA UNII | 64E5D8C741 |
SONGORINE Chemical Properties,Uses,Production
Description
Both Aconitum karakoZicum and A. soongoricum contain this atisine type alkaloid which is strongly laevorotatory with [α]D - 139.89°. The ultraviolet spectrum contains a single absorption maximum at 290 mil. Several crystalline salts and derivatives are known including the hydrochloride, m.p. 257-8°C; [α]D - 113.99° (H20); hydrobromide, m.p. 261°C; nitrate, m.p. 230-l oC (dec.); perchlorate, m.p. 234-5°C (dec.); methiodide, m.p. 2l3-4°C (dec.) and the semicarbazone, m.p. 247-8°C (dec.). Catalytic hydrogenation over Pt02 gives the dihydro derivative, m.p. 205-6°C, giving a hydrochloride, m.p. 286- 7°C and a methiodide, m.p. 255-6°C. With AcCl the alkaloid yields the diacetyl derivative, m.p. l80-2°C, forming a hydrochloride dihydrate, m.p. 239-240°C. When boiled with KOH for 2 hours, the base gives des-N-methylsongorine, isolated as the hydrochloride, m.p. 285°C.
Biological Activity
Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C20 diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions.
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties.
References
Yunusov.,J. Gen. Chem., USSR, 18, 515 (1948)
Wiesner et al., Chem. Ind., 173 (1957)
Yunusovetal., Khim. Prir. Soedin., 6, 101 (1970)
Structure:
Wiesner, Ito, Valenta., Experientia, 14,167 (1958)
Sugasawa., Chem. Pharm. Bull. (Tokyo), 9, 897 (1961)
Absolute configuration:
Okamoto et al., Chem. Pharm. Bull. (Tokyo), 13, 1270 (1965)
SONGORINE Preparation Products And Raw materials
Raw materials
Preparation Products
SONGORINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Aktin Chemicals, Inc. | 86-28-85159085 | info@aktinchem.com | China | 297 | 62 |
Supplier | Advantage |
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Aktin Chemicals, Inc. | 62 |
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