SD-208
- CAS No.
- 627536-09-8
- Chemical Name:
- SD-208
- Synonyms
- SD-208;SCI 208;CS-2295;SD-208 10MG;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;SD-208, 10 mM in DMSO;TGF-β RI Kinase Inhibitor V;SD-208;SD 208; SD208; SCI 208
- CBNumber:
- CB7837155
- Molecular Formula:
- C17H10ClFN6
- Molecular Weight:
- 352.75
- MDL Number:
- MFCD09038685
- MOL File:
- 627536-09-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SD-208 price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7071 | SD-208 ≥98% (HPLC), powder | 627536-09-8 | 5mg | $211 | 2024-03-01 | Buy |
| Sigma-Aldrich | S7071 | SD-208 ≥98% (HPLC), powder | 627536-09-8 | 25mg | $306.4 | 2024-03-01 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 5mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 10mg | $178 | 2024-03-01 | Buy |
SD-208 Chemical Properties,Uses,Production
Uses
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
in vivo
SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice[1]. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases[2]. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)[3].
storage
Store at RT
SD-208 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22858 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
