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| Product Name: | SD-208 | | Synonyms: | SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-;2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;SCI 208;2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl- | | CAS: | 627536-09-8 | | MF: | C17H10ClFN6 | | MW: | 352.75 | | EINECS: | | | Product Categories: | Inhibitors;Smad;TGF-beta | | Mol File: | 627536-09-8.mol |  |
| | SD-208 Chemical Properties |
| Boiling point | 460.4±45.0 °C(Predicted) | | density | 1.487 | | storage temp. | 2-8°C | | solubility | DMSO: >5mg/mL | | pka | 4.56±0.26(Predicted) | | form | powder | | color | off-white to tan |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | SD-208 Usage And Synthesis |
| Uses | SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2 | | Biological Activity | Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. | | Biochem/physiol Actions | SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1 | | storage | Store at RT |
| | SD-208 Preparation Products And Raw materials |
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