Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
![Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Structure](CAS/20210305/GIF/2489196-70-3.gif)
- CAS No.
- 2489196-70-3
- Chemical Name:
- Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
- Synonyms
- mTOR-IN-8;mTOR inhibitor-8;Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]-
- CBNumber:
- CB78379626
- Molecular Formula:
- C24H19ClN4OS
- Molecular Weight:
- 446.95
- MDL Number:
- MOL File:
- 2489196-70-3.mol
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Properties
| Boiling point | 626.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 25 mg/mL (55.93 mM; Need ultrasonic) |
| pka | 3.00±0.10(Predicted) |
| form | Solid |
| color | White to yellow |
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 10mg | $480 | 2021-12-16 | Buy |
| ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 50mg | $1450 | 2021-12-16 | Buy |
| ChemScene | CS-0133446 | mTORinhibitor-8 98.04% | 2489196-70-3 | 100mg | $2250 | 2021-12-16 | Buy |
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Chemical Properties,Uses,Production
Biological Activity
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1]. mTOR inhibitor-8 (Compound 5e; 0.1-10 μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner[1].mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10 μM; 3-24 hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced[1].mTOR inhibitor-8 (10 μM; 3-24 hours) reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR[1] mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis[1].
References
[1]. ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551.
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine, 4-[2-[3-(4-chlorophenyl)-4,5-dihydro-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]-4-thiazolyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 18616537568 | hanfangpharma@126.com | China | 30968 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 55 |
| Nantong Hanfang Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |