ChemicalBook >> CAS DataBase List >>5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
- CAS No.
- 2143452-22-4
- Chemical Name:
- 5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
- Synonyms
- TSHR antagonist S37b;TSHR antagonist S37b,TSHR antagonist S-37b;5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
- CBNumber:
- CB78380585
- Molecular Formula:
- C25H20N2O3S2
- Molecular Weight:
- 460.57
- MDL Number:
- MOL File:
- 2143452-22-4.mol
Last updated:2024-07-02 08:55:17
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)- Properties
Density | 1.54±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility | DMSO : 100 mg/mL (217.12 mM; Need ultrasonic) |
pka | 9.16±0.40(Predicted) |
form | Solid |
color | Off-white to light yellow |
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0109000 | TSHRantagonistS37b | 2143452-22-4 | 5mg | $480 | 2021-12-16 | Buy |
ChemScene | CS-0109000 | TSHRantagonistS37b | 2143452-22-4 | 10mg | $800 | 2021-12-16 | Buy |
ChemScene | CS-0109000 | TSHRantagonistS37b | 2143452-22-4 | 25mg | $1550 | 2021-12-16 | Buy |
ChemScene | CS-0109000 | TSHRantagonistS37b | 2143452-22-4 | 50mg | $2400 | 2021-12-16 | Buy |
ChemScene | CS-0109000 | TSHRantagonistS37b | 2143452-22-4 | 100mg | $3600 | 2021-12-16 | Buy |
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)- Chemical Properties,Uses,Production
Biological Activity
TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a . TSHR antagonist S37b shows only a minor effect for thyrotropin receptor (TSHR) inhibition. TSHR antagonist S37b can be used for the research of thyroid function[1].
References
[1]. Marcinkowski P, et al. A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves’ Orbitopathy. Thyroid. 2019 Jan;29(1):111-123.
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)- Preparation Products And Raw materials
Raw materials
Preparation Products
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)- Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5014 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-, (4aR,5R,5aS,8aS,9S,9aR,10S)-
TSHR antagonist S37b
TSHR antagonist S37b,TSHR antagonist S-37b
2143452-22-4