ChemicalBook >> CAS DataBase List >>5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE structure

CAS No.: 874902-19-9

Chemical Name:: 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

Synonyms: CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;LY2183240, 10 mM in DMSO;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-

CBNumber:: CB7842012

Molecular Formula:: C17H17N5O

Molecular Weight:: 307.35

MDL Number:: MFCD08703123

MOL File:: 874902-19-9.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Properties

Melting point	87-88℃
Boiling point	506.1±53.0 °C(Predicted)
Density	1.21
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
pka	0.01±0.10(Predicted)
form	White to off-white solid.
color	White
Stability	Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
FDA UNII	2WBU91OKM7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

Hazard Codes

Risk Statements

NFPA 704

	0
2		0

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10008663	LY2183240 ≥98%	874902-19-9	1mg	$93	2024-03-01	Buy
Cayman Chemical	10008663	LY2183240 ≥98%	874902-19-9	5mg	$252	2024-03-01	Buy
Tocris	2452	LY2183240 ≥98%(HPLC)	874902-19-9	1	$112	2021-12-16	Buy
Tocris	2452	LY2183240 ≥98%(HPLC)	874902-19-9	10	$237	2021-12-16	Buy
TRC	L503140	LY2183240	874902-19-9	250mg	$790	2021-12-16	Buy

Product number	Packaging	Price	Buy
10008663	1mg	$93	Buy
10008663	5mg	$252	Buy
2452	1	$112	Buy
2452	10	$237	Buy
L503140	250mg	$790	Buy

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Chemical Properties,Uses,Production

Description

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.

Uses

LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids

Definition

ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

in vivo

LY2183240 (3-30mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms^[1].

Animal Model:	Male Sprague-Dawley rats (Formalin Pain Model)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	I.p.
Result:	Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.

References

1) Moore et al., (2005), Identification of a high-affinity binding site involved in the transport of endocannabinoids; Proc. Natl. Acad. Sci. USA, 102 17852 2) Ortar et al. (2008), Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revision; Eur. .J. Med. Chem., 43 62 3) Alexander and Cravatt (2006), The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases; J. Am. Chem. Soc., 128 9699 4) Dickason-Chesterfield et al. (2006), Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors; Cell. Mol. Neurobiol., 26 405

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
Qiuxian Baitai New Material Co., LTD	+8618330912755	sale2@hbyalin.com	China	1658	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3084	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Shanghai Quedan biology science and technology co., ltd	+86-13004146052	lnzc@quedan.com.cn	China	1022	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	9875	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
Qiuxian Baitai New Material Co., LTD	58
RongNa Biotechnology Co.,Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Shanghai Quedan biology science and technology co., ltd	58
Changzhou AniKare Pharmatech Co., Ltd.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-11-15	LY2183240 powder 874902-19-9	US $29.00 / KG	1KG	99%	500ton/Month	Qiuxian Baitai New Material Co., LTD
	2020-01-10	N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 874902-19-9	US $1.00 / g	1g	99%	200kg	Career Henan Chemical Co

LY2183240 powder
874902-19-9
US $29.00 / KG
99%
Qiuxian Baitai New Material Co., LTD

N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
874902-19-9
US $1.00 / g
99%
Career Henan Chemical Co

874902-19-9(5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE)Related Search:

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE 1H-TETRAZOLE, 5-(P-METHYLBENZYL)-

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE LY 2183240 LY-2183240 MN-25 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl- 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide LY2183240/LY-2183240 CS-752 LY2183240 powder Inhibitor,brain,uptake,transport,hydrolases,Fatty acid amide hydrolase,LY2183240,Autophagy,LY 2183240,serine,anandamide,FAAH,inhibit,LY-2183240 5- ([1,1 '- biphenyl] -4-methyl) - N, N-dimethyl-1H-tetrazol-1-formamide LY2183240, 10 mM in DMSO 874902-19-9