Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester
- CAS No.
- 1310817-94-7
- Chemical Name:
- Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester
- Synonyms
- RO-5328673;Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester
- CBNumber:
- CB78531404
- Molecular Formula:
- C29H32Cl2FN3O4
- Molecular Weight:
- 576.49
- MDL Number:
- MOL File:
- 1310817-94-7.mol
Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester Chemical Properties,Uses,Production
Description
RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of gp SNpc, RO5328673 inhibited the senktide-induced potentiation of spontaneous activity of dopaminergic neurons with an insurmountable mechanism of action. RO5328673 exhibited in-vivo activity in gerbils, robustly reversing the senktide-induced locomotor activity.
Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Carbamic acid, N-[(3S,4R)-4-(3,4-dichlorophenyl)-1-[[1-[(1-methylcyclopropyl)carbonyl]-4-piperidinyl]carbonyl]-3-pyrrolidinyl]-N-methyl-, 4-fluorophenyl ester Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |