Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Structure
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- structure
CAS No.
892415-28-0
Chemical Name:
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-
Synonyms
F2005-0304;ω- transaminase;EAAT2 activator 1;3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine;Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-;GLT-1,Excitatory amino acid transporter 2,inhibit,Glutamate transporter 1,Inhibitor,EAAT-2 activator 1,EAAT2 activator 1,EAAT2,glutamate transporter,synapse
CBNumber:
CB78630299
Molecular Formula:
C16H11ClFN3S
Molecular Weight:
331.8
MDL Number:
MOL File:
892415-28-0.mol
Last updated:2024-07-02 08:55:17
Request For Quotation

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Properties

Boiling point 527.6±50.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (75.35 mM; ultrasonic and warming and heat to 60°C)
pka 0.65±0.19(Predicted)
form Solid
color Light brown to brown

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Chemical Properties,Uses,Production

Biological Activity

EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently[1].

References

[1]. Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777.

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		+86-0512-83500002 +8615195660023 sales@senfeida.com China 23053 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3717 55
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Nantong Zhonghe Chemical New Materials Co., Ltd 13003551299 13003551299 2369399482@qq.com China 7567 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9155 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 		58
Aladdin Scientific 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Nantong Zhonghe Chemical New Materials Co., Ltd 58
RD International Technology Co., Limited 58
Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)- EAAT2 activator 1 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine F2005-0304 GLT-1,Excitatory amino acid transporter 2,inhibit,Glutamate transporter 1,Inhibitor,EAAT-2 activator 1,EAAT2 activator 1,EAAT2,glutamate transporter,synapse ω- transaminase 892415-28-0