1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)-

1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- structure

CAS No.: 10442-95-2

Chemical Name:: 1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)-

Synonyms: PNF1;2-(2-Oxocyclopentyl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)-

CBNumber:: CB78787863

Molecular Formula:: C13H11NO3

Molecular Weight:: 229.23

MDL Number:

MOL File:: 10442-95-2.mol

Last updated:2023-04-23 13:52:06

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1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- Properties

Melting point	175-177 °C
Boiling point	393.5±35.0 °C(Predicted)
Density	1.419±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (35 mg/ml)
form	solid
pka	-2.45±0.20(Predicted)
color	Off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- Chemical Properties,Uses,Production

Description

PNF1 (10442-95-2) is a novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-α followed by TGF-β signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4

References

Wieghaus et al. (2006) Small molecule inducers of angiogenesis for tissue engineering; Tissue Eng. 12 1903 Wieghaus et al. (2008) Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1); Biomaterials 29 4698 Wieghaus et al. (2008) Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule; Bioinformatics 24 2384 Wieghaus et al. (2009) Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells; Biotechnol. Bioeng. 103 796

1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaoyuan Technology (Shanghai) Co., Ltd.	021-50795510 4000665055	sy-c5@accelachem.com	China	10349	58

Supplier	Advantage
Shaoyuan Technology (Shanghai) Co., Ltd.	58

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1H-Isoindole-1,3(2H)-dione, 2-(2-oxocyclopentyl)- PNF1 2-(2-Oxocyclopentyl)isoindoline-1,3-dione 10442-95-2