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ChemicalBook >> CAS DataBase List >>2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-

2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-

2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Structure
2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- structure
CAS No.
2253879-65-9
Chemical Name:
2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-
Synonyms
BCL6-IN-4;BCL-6-IN-4,BCL6 IN 4,BCL6IN4;2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-
CBNumber:
CB78789665
Molecular Formula:
C25H35ClN6O3
Molecular Weight:
503.04
MDL Number:
MFCD33548856
MOL File:
2253879-65-9.mol
Last updated:2024-07-02 08:55:17
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2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Properties

Boiling point 647.3±65.0 °C(Predicted)
Density 1.237±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 73.33 mg/mL (145.77 mM; Need ultrasonic)
pka 15.14±0.29(Predicted)
form Solid
color White to light brown

2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Chemical Properties,Uses,Production

Biological Activity

BCL6-IN-4 is a potent B-cell lymphoma 6 (BCL6) inhibitor with an IC50 of 97 nM. BCL6-IN-4 has anti-tumor activities[1]. BCL6-IN-4 (compound 25b) inhibits OCI-Ly1 and OCI-Ly3 cell lines growth with GI50 values of 2.8 μM and 4.2 μM, respectively[1].

References

[1]. Benjamin R Bellenie, et al. Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J Med Chem. 2020 Apr 23;63(8):4047-4068.

2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Hefei fuya biotechnology co. LTD 18096409024 sales02@foreversyn.com China 1979 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7980 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9268 58
Supplier Advantage
Aladdin Scientific 		58
Hefei fuya biotechnology co. LTD 58
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
RD International Technology Co., Limited 58
2H-Benzimidazol-2-one, 5-[[5-chloro-2-(2,2,6,6-tetramethyl-4-morpholinyl)-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl- BCL6-IN-4 BCL-6-IN-4,BCL6 IN 4,BCL6IN4 2253879-65-9 C25H35ClN6O3