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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- structure

CAS No.: 2313525-90-3

Chemical Name:: Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

Synonyms: Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-;HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110

CBNumber:: CB78843943

Molecular Formula:: C25H23F3N2O3

Molecular Weight:: 456.47

MDL Number:

MOL File:: 2313525-90-3.mol

Last updated:2024-07-02 08:55:17

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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Properties

Density	1.247±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Ethanol: soluble
form	A solid
pka	12.15±0.46(Predicted)
color	Light yellow to yellow

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Chemical Properties,Uses,Production

Biological Activity

LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 μM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.

References

1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Chengdu Chuangkecheng Biological Technology Co., Ltd.	028-028-0000000 13008177686	sales@ckcbiotech.com	China	738	55
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	376	55
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Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2985	58

Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
LEAPCHEM CO., LTD.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Chengdu Chuangkecheng Biological Technology Co., Ltd.	55
Shanghai Beckham Medical Technology Co., Ltd	55
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Rechem science Co., Ltd.	58

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110 2313525-90-3