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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2624131-45-7
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
PW0787;GPR52,PW-0787,oral,PW0787,Inhibitor,PW 0787,brain-penetrant,selective,inhibit,psychostimulant,behavior
CBNumber:
CB78896424
Molecular Formula:
C23H20F4N4O2
Molecular Weight:
460.43
MDL Number:
MFCD33550902
MOL File:
2624131-45-7.mol
Last updated:2024-07-02 08:55:17
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INDEX NAME NOT YET ASSIGNED Properties

Boiling point 605.1±55.0 °C(Predicted)
Density 1.388±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 50 mg/mL (108.60 mM; Need ultrasonic)
form Solid
pka 14.18±0.20(Predicted)
color Off-white to yellow

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior[1]. PW0787 (0.3, 1, 3, or 10 mg/kg; IP) displays antipsychotic-like activity by significantly inhibiting amphetamine-induced hyperlocomotor behavior in mice[1].PW0787 is evaluated in rats after a single dose of 20 mg/kg by oral (PO) or 10 mg/kg by intravenous (IV) administration. PW0787 has excellent plasma exposure after PO (AUC0-inf = 13,749 ng?h/mL) and IV dosing (AUC0-inf=9030 ng?h/mL), as well as high maximum serum concentration following PO (Cmax=3407 ng/mL) and IV administration (Cmax=6726 ng/mL). Additionally, PW0787 displays good volume of plasma distribution (Vss=1.5 L/kg) and acceptable plasma clearance (CL=1.1 L/h/kg) after 10 mg/kg IV. Excellent oral bioavailability (F) with the value of 76% is observed[1].

References

[1]. Wang P, et al. Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem. 2020;63(22):13951-13972.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9874 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 884 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Aikon International Limited 18626450290 yftan@aikonchem.com China 10718 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5595 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29990 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5014 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Aikon International Limited 58
Nanjing Tengyi Biotechnology Co., Ltd 58
https://hanhongsci.com/ 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58

INDEX NAME NOT YET ASSIGNED Spectrum

INDEX NAME NOT YET ASSIGNED(2624131-45-7)1HNMR
PW0787 GPR52,PW-0787,oral,PW0787,Inhibitor,PW 0787,brain-penetrant,selective,inhibit,psychostimulant,behavior 2624131-45-7