N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide
![N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide Structure](CAS/GIF/51484-40-3.gif)
- CAS No.
- 51484-40-3
- Chemical Name:
- N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide
- Synonyms
- Difenpyramide;difenpiramide;N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide;N-(2-Pyridinyl)-1,1'-biphenyl-4-acetamide;2-(4-phenylphenyl)-N-pyridin-2-ylacetamide;[1,1'-Biphenyl]-4-acetamide, N-2-pyridinyl-;2-([1,1'-Biphenyl]-4-yl)-N-(pyridin-2-yl)acetamide;2-([1,1'-Biphenyl]-4-yl)-N-(pyridin-2-yl)acetamide
- CBNumber:
- CB7913600
- Molecular Formula:
- C19H16N2O
- Molecular Weight:
- 288.34
- MDL Number:
- MFCD00869423
- MOL File:
- 51484-40-3.mol
| Melting point | 122-124° |
|---|---|
| form | Solid |
| color | Light brown to brown |
| FDA UNII | Q6U5F6E1QL |
| ATC code | M01AB12 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Toxicity | LD50 in male mice, rats (mg/kg): 2590, 2075 orally; 1421, 1396 i.p. (Caliari) |
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide Chemical Properties,Uses,Production
Originator
Difenax,Zambeletti,Italy,1977
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group from biphenyl-4-ylacetic acid with the amino group of 2-aminopyridine. Used for treatment of rheumatoid arthritis.
Manufacturing Process
23 g (0.1 mol) diphenylacetic acid chloride dissolved in 300 cc anhydrous
ethyl ether are slowly added dropwise to a solution of 19 g (0.2 mol) 2-
aminopyridine in 300 cc anhydrous ethyl ether. The reaction mixture is
agitated and the temperature is kept at between 5°C and 10°C with an ice
bath. After the addition has been completed, the agitation of the mixture is
continued and the temperature is allowed to rise to 20°C to 25°C.
After leaving to stand for a few hours, the gummy precipitate solidifies and
becomes filterable. After separating off the precipitate, the ether is evaporated
under reduced pressure to a volume of about 100 cc.
The ether is left to stand at a low temperature below 10°C when the
remaining portion of the product precipitates and is filtered off and added to
the first precipitate. The product thus obtained is thoroughly washed, first in
water and then in a solution of sodium bicarbonate, and then again in water.
After drying in air, the product is crystallized from anhydrous ethanol or from
acetone and water. The analytical data correspond to calculated values. Yield
is 18 g; MP 122°C to 124°C.
Therapeutic Function
Antiinflammatory
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide Preparation Products And Raw materials
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4966 | 55 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 9310 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 9997 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 54986 | 58 |
| Atomic chemistry | 03702785705 17550071527 | 2711558945@qq.com | China | 4175 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 978 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50471 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 15026420323 | sunchao@jskchem.com | China | 49242 | 58 |