magnessium lithospermate B
- CAS No.
- 122021-74-3
- Chemical Name:
- magnessium lithospermate B
- Synonyms
- Magnesium Salvianolate B;Magnesium Lithospermate B;magnessium lithospermate B;Monomethyl lithospermate B;MAGNESIUM LITHOSPERMATE B 98%;Magnesium Lithospermate B, 10 mM in DMSO;magnesium,2-[(E)-3-[3-[1-carboxylato-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoate
- CBNumber:
- CB7980918
- Molecular Formula:
- C36H28MgO16
- Molecular Weight:
- 740.90292
- MDL Number:
- MFCD00914300
- MOL File:
- 122021-74-3.mol
- MSDS File:
- SDS
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
|---|---|
| form | Powder |
| color | Light yellow to light brown |
| FDA UNII | 8V4R1E4C5Y |
magnessium lithospermate B price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | N2234 | MonomethyllithospermateB | 122021-74-3 | 5mg | $450 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb104759 | Monomethyl lithospermate B >98%,Standard References Grade | 122021-74-3 | 20mg | $569.5 | 2021-12-16 | Buy |
| DC Chemicals | DCD-054 | MonomethyllithospermateB >98%,StandardReferencesGrade | 122021-74-3 | 20mg | $280 | 2021-12-16 | Buy |
| Arctom | CFN90390 | MagnesiumLithospermateB | 122021-74-3 | 5mg | $320 | 2021-12-16 | Buy |
magnessium lithospermate B Chemical Properties,Uses,Production
Uses
Magnesium Lithospermate B, is a derivative of caffeic acid tetramer and an inhibitor of Na+/K+ ATPase, which can be extracted from Salviae miltiorrhizae. Magnesium Lithospermate B is widely used for the research of cardiovascular diseases, and it can protect against glucose-induced intracellular oxidative damage. Magnesium Lithospermate B also suppresses neuroin?ammation and attenuates neurodegeneration[1][2][3].
in vivo
Magnesium Lithospermate B (2-8 mg/kg; p.o. once daily for 16 d) reduces the renal damage of oxidative stress through reduction of reactive oxygen species in old rats[1].
Magnesium Lithospermate B (0.5 μg/g; s.c. for 6 weeks) promotes the neurogenesis and improves the memory in PD models[3].
| Animal Model: | Young (5-month-old) and old (20-month-old) specific-pathogen-free male Sprague-Dawley rats[1] |
| Dosage: | 2, 8 mg/kg |
| Administration: | P.o. once daily for 16 days |
| Result: | Reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho-p38, nuclear factor-kappa B p65, cyclooxygenase-2, and inducible nitric oxide synthase. Showed lower levels of senescence-related proteins such as p16, ADP-ribosylation factor 6, p53, and p21. |
target
p65 | NF-kB | TGF-β/Smad | ROS | PDGFR
References
[1] Magnesium lithospermate B possesses inhibitory activity on Na+,K+‐ATPase and neuroprotective effects against ischemic stroke
[2] Park CH, et, al. Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging-Induced Renal Inflammation and Senescence via NADPH Oxidase-Mediated Reactive Oxygen Generation. Phytother Res. 2017 May;31(5):721-728. DOI:10.1002/ptr.5789
[3] Quan W, et, al. Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro. J Tradit Chin Med. 2013 Feb; 33(1): 85-91. DOI:10.1016/s0254-6272(13)60106-5
[4] Zhang Z, et, al. Magnesium lithospermate B promotes proliferation and differentiation of neural stem cells in vitro and enhances neurogenesis in vivo. Tissue Cell. 2018 Aug; 53:8-14. DOI:10.1016/j.tice.2018.05.012
magnessium lithospermate B Preparation Products And Raw materials
Raw materials
Preparation Products
magnessium lithospermate B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Mensura Group Limited | +8618109034517 | 1058503172@qq.com | China | 2900 | 58 |
| Shanghai Moqi Biological Technology Co., LTD | 021-38218169 13341702378 | 190129269@qq.com | China | 9911 | 58 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Shanghai Winherb Medical Technology Co., Ltd. | 400-186-5138 13341702378 | winherb@126.com | China | 1010 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12335 | 58 |
| Shanghai BeiZhuo Biotech Co., Ltd. | 021-61119791,13386096464 | bzswkf@foxmail.com | China | 3921 | 50 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-+86-571-87396432 | sales@jhechem.com | China | 11849 | 59 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9872 | 58 |
View Lastest Price from magnessium lithospermate B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-14 | Magnesium Lithospermate B
122021-74-3
|
US $115.00-368.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. |
-
- Magnesium Lithospermate B
122021-74-3
- US $115.00-368.00 / mg
- 99.87%
- TargetMol Chemicals Inc.
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