2-Acetylbutyrolactone
- CAS No.
- 517-23-7
- Chemical Name:
- 2-Acetylbutyrolactone
- Synonyms
- ABL;3-acetyldihydrofuran-2(3H)-one;ABL1;ACETYLBUTYROLACTONE;2-Acetylbutyrolacton;-Acetyl-hydroxybutyricacid;2-Oxo-3-acetyltetrahydrofuran;JTK7;p190;bcr/abl
- CBNumber:
- CB8101532
- Molecular Formula:
- C6H8O3
- Molecular Weight:
- 128.13
- MDL Number:
- MFCD00005394
- MOL File:
- 517-23-7.mol
- MSDS File:
- SDS
| Melting point | <25 °C |
|---|---|
| Boiling point | 107-108 °C5 mm Hg(lit.) |
| Density | 1.19 g/mL at 25 °C(lit.) |
| vapor pressure | 0.131Pa at 20℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 200g/l |
| pka | 12.00±0.20(Predicted) |
| form | Liquid |
| color | Clear |
| biological source | human |
| Water Solubility | 310 g/L (20 ºC) |
| Merck | 14,83 |
| BRN | 112676 |
| Specific Activity | 717-971nmol/min·mg |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| LogP | -0.43 at 22℃ |
| CAS DataBase Reference | 517-23-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I3D73T5K0Q |
| NIST Chemistry Reference | 2(3H)-Furanone, 3-acetyldihydro-(517-23-7) |
| EPA Substance Registry System | 2(3H)-Furanone, 3-acetyldihydro- (517-23-7) |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H360D | |||||||||
| Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-61 | |||||||||
| Safety Statements | 26-36-37/39-45-53 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | LU3456000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29322980 | |||||||||
| NFPA 704 |
|
2-Acetylbutyrolactone price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A13409 | α-Acetylbutyrolactone ≥99% | 517-23-7 | 100g | $41.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | A13409 | α-Acetylbutyrolactone ≥99% | 517-23-7 | 500g | $45.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | A0608 | ABL1 (27-end), active, His-tagged from mouse PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 517-23-7 | 10μG | $522 | 2024-03-01 | Buy |
| Sigma-Aldrich | SRP5279 | ABL1, active, His tagged human PRECISIO?, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 153190-62-6 | 10μG | $498 | 2023-06-20 | Buy |
| TCI Chemical | A0681 | alpha-Acetyl-gamma-butyrolactone >99.0%(GC) | 517-23-7 | 25g | $23 | 2024-03-01 | Buy |
2-Acetylbutyrolactone Chemical Properties,Uses,Production
Description
It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4
Reference
- Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
- Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
- Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
- Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.
Chemical Properties
Colorless to light yellow liqui
Uses
In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.
Uses
An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.
Definition
ChEBI: 3-Acetyldihydro-2(3H)-furanone is a gamma-lactone.
Flammability and Explosibility
Not classified
Biological Activity
ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase th at has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.
2-Acetylbutyrolactone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | sales@blitchem.com | China | 293 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20234 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
View Lastest Price from 2-Acetylbutyrolactone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | 2-Acetylbutyrolactone
517-23-7
|
US $0.00 / kg | 1kg | 99% | 5000mt | Jinan Finer Chemical Co., Ltd | |
 |
2025-04-15 | 2-Acetylbutyrolactone
517-23-7
|
US $0.00 / kg | 20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | |
 |
2025-04-11 | 2-Acetylbutyrolactone
517-23-7
|
US $0.00 / KG | 1KG | 99% | 1500 TONS | BLiT (Hefei)Chemical Co.,Ltd |
-
- 2-Acetylbutyrolactone
517-23-7
- US $0.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 2-Acetylbutyrolactone
517-23-7
- US $0.00 / kg
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 2-Acetylbutyrolactone
517-23-7
- US $0.00 / KG
- 99%
- BLiT (Hefei)Chemical Co.,Ltd
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