2-Acetylbutyrolactone
- CAS No.
- 517-23-7
- Chemical Name:
- 2-Acetylbutyrolactone
- Synonyms
- ABL;3-acetyldihydrofuran-2(3H)-one;ABL1;ACETYLBUTYROLACTONE;2-Acetylbutyrolacton;-Acetyl-hydroxybutyricacid;2-Oxo-3-acetyltetrahydrofuran;JTK7;p190;bcr/abl
- CBNumber:
- CB8101532
- Molecular Formula:
- C6H8O3
- Molecular Weight:
- 128.13
- MDL Number:
- MFCD00005394
- MOL File:
- 517-23-7.mol
- MSDS File:
- SDS
Melting point | <25 °C |
---|---|
Boiling point | 107-108 °C5 mm Hg(lit.) |
Density | 1.19 g/mL at 25 °C(lit.) |
vapor pressure | 0.131Pa at 20℃ |
refractive index |
n |
Flash point | >230 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 200g/l |
form | Liquid |
pka | 12.00±0.20(Predicted) |
color | Clear |
Water Solubility | 310 g/L (20 ºC) |
Merck | 14,83 |
BRN | 112676 |
Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
LogP | -0.43 at 22℃ |
CAS DataBase Reference | 517-23-7(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | I3D73T5K0Q |
NIST Chemistry Reference | 2(3H)-Furanone, 3-acetyldihydro-(517-23-7) |
EPA Substance Registry System | 2(3H)-Furanone, 3-acetyldihydro- (517-23-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H315-H319-H360D | |||||||||
Precautionary statements | P202-P264-P280-P302+P352-P305+P351+P338-P308+P313 | |||||||||
Hazard Codes | Xi,T | |||||||||
Risk Statements | 36/37/38-61 | |||||||||
Safety Statements | 26-36-37/39-45-53 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | LU3456000 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29322980 | |||||||||
NFPA 704 |
|
2-Acetylbutyrolactone price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A13409 | α-Acetylbutyrolactone ≥99% | 517-23-7 | 100g | $41.1 | 2024-03-01 | Buy |
Sigma-Aldrich | A13409 | α-Acetylbutyrolactone ≥99% | 517-23-7 | 500g | $45.4 | 2024-03-01 | Buy |
Sigma-Aldrich | A0608 | ABL1 (27-end), active, His-tagged from mouse PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 517-23-7 | 10μG | $522 | 2024-03-01 | Buy |
Sigma-Aldrich | SRP5279 | ABL1, active, His tagged human PRECISIO?, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 153190-62-6 | 10μG | $498 | 2023-06-20 | Buy |
TCI Chemical | A0681 | alpha-Acetyl-gamma-butyrolactone >99.0%(GC) | 517-23-7 | 25g | $23 | 2024-03-01 | Buy |
2-Acetylbutyrolactone Chemical Properties,Uses,Production
Description
It is an important intermediate involved in the synthesis of chemical and pharmaceutical products such as vitamin B, 3,4-substituted pyridine, 5-(2-Hydroxyethyl)-4-methylthiazole. In presence of 2-acetylbutyrolactone, reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates.1 Moreover, reaction of 2-acetylbutyrolactone with thiosemicarbazide and 3-(2-bromo-acetyl)-chromen-2-one in anhydrous ethanol produced 3-{2-[5-hydroxyl-4-(2-hydroxyl-ethyl)-3-methyl-pyrazol-1-yl]-thiazol-4-yl}-chromen-2-one in good yields.2 In addition, 2-acetylbutyrolactone can also function as the raw material for synthesizing pilocarpine that is a leading therapeutic agent for the treatment of narrow and wide angle glaucoma.3 Besides, this chemical can also act as a fluorogenic reagent in the quantitative spectrofluorometric determination of primary amines, which has been demonstrated to be equally accurate and precise as the officially or other reported methods.4
Reference
- Asghari, S.; Mohammadi, L., Reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone. Synthesis of functionalized alpha-methylene-gamma-butyrolactones. Tetrahedron Lett. 2006, 47, 4297-4299.
- Rao, V. R.; Kumar, P. V., Facile one-pot synthesis of 3-{25-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-pyrazol-1-yl -thiazol-4-yl} -chromen-2-ones via a three-component reaction. Synth. Commun. 2006, 36, 2157-2161.
- Horne, D. A.; Fugmann, B.; Yakushijin, K.; Buchi, G., A SYNTHESIS OF PILOCARPINE. J. Org. Chem. 1993, 58, 62-64.
- Sabry, S. M., Application of 2-acetylbutyrolactone to spectrofluorinietry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. J. Pharm. Biomed. Anal. 2006, 40, 1057-1067.
Chemical Properties
Colorless to light yellow liqui
Uses
An intermediate in the synthesis of 2,4-disubstituted pyridines. A fluorogenic reagent for the spectrofluorimetric determination of primary amines.
Uses
In synthesis of 3,4-disubstituted pyridines; of 5-(b-hydroxethyl)-4-methylthiazole.
Definition
ChEBI: 3-Acetyldihydro-2(3H)-furanone is a gamma-lactone.
Flammability and Explosibility
Not classified
2-Acetylbutyrolactone Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | sales@blitchem.com | China | 293 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1009 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2989 | 55 |
View Lastest Price from 2-Acetylbutyrolactone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-30 | 2-Acetylbutyrolactone
517-23-7
|
US $0.00 / kg | 1kg | 99% | 5000mt | Jinan Finer Chemical Co., Ltd | ||
2024-09-30 | 2-Acetylbutyrolactone
517-23-7
|
US $0.00 / KG | 1KG | 99% | 1500 TONS | BLiT (Hefei)Chemical Co.,Ltd | ||
2024-09-29 | 2-Acetylbutyrolactone
517-23-7
|
US $10.00 / KG | 1KG | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
- 2-Acetylbutyrolactone
517-23-7
- US $0.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
- 2-Acetylbutyrolactone
517-23-7
- US $0.00 / KG
- 99%
- BLiT (Hefei)Chemical Co.,Ltd
- 2-Acetylbutyrolactone
517-23-7
- US $10.00 / KG
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
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