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RK-682

CAS No.
154639-24-4
Chemical Name:
RK-682
Synonyms
RK-682;TAN 1364B;(Rac)-RK-682;ANTIBIOTIC RK-682;ANTIBIOTIC TAN 1364B;RK-682, STREPTOMYCES SPECIES;3-HEXADECANOYL-5-HYDROXYMETHYL-TETRONIC ACID;CI 010, 3-hexadecanoyl-5-hydroxyMethyltetronic acid.;2(5H)-Furanone, 4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-
CBNumber:
CB9706972
Molecular Formula:
C21H36O5
Molecular Weight:
368.51
MDL Number:
MFCD09752706
MOL File:
154639-24-4.mol
Last updated:2023-05-21 10:59:17

RK-682 Properties

Boiling point 546.7±50.0 °C(Predicted)
Density 1.073±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Methanol: soluble
form Pale yellow solid.
pka 1.80±0.10(Predicted)

RK-682 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 27964 TAN 1364B 154639-24-4 500μg $299 2024-03-01 Buy
Cayman Chemical 27964 TAN 1364B 154639-24-4 2.5mg $1189 2024-03-01 Buy
Usbiological A2297-30 Antibiotic RK-682 154639-24-4 500ug $482 2021-12-16 Buy
AK Scientific 2042DM RK-682,Streptomycessp. 154639-24-4 2.5mg $1423 2021-12-16 Buy
Product number Packaging Price Buy
27964 500μg $299 Buy
27964 2.5mg $1189 Buy
A2297-30 500ug $482 Buy
2042DM 2.5mg $1423 Buy

RK-682 Chemical Properties,Uses,Production

Description

TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 μM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.

Uses

TAN 1364B is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)

Uses

TAN 1364B (RK-682) is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)

RK-682 Preparation Products And Raw materials

Raw materials

Preparation Products

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RK-682 RK-682, STREPTOMYCES SPECIES 3-HEXADECANOYL-5-HYDROXYMETHYL-TETRONIC ACID CI 010, 3-hexadecanoyl-5-hydroxyMethyltetronic acid. TAN 1364B ANTIBIOTIC RK-682 ANTIBIOTIC TAN 1364B 2(5H)-Furanone, 4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)- (Rac)-RK-682 154639-24-4