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2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- structure

CAS No.: 2094893-05-5

Chemical Name:: 2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-

Synonyms: EN523;4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one;2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-;inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23

CBNumber:: CB810744792

Molecular Formula:: C12H14N2O3

Molecular Weight:: 234.25

MDL Number:

MOL File:: 2094893-05-5.mol

Last updated:2024-07-02 08:55:17

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2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Properties

Boiling point	529.6±50.0 °C(Predicted)
Density	1.225±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (1067.24 mM; Need ultrasonic)
pka	-0.21±0.20(Predicted)
form	Solid
color	White to off-white

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Chemical Properties,Uses,Production

Biological Activity

EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1[1].

References

[1]. Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Suppliers

Global( 20)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
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Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Zhengzhou Converging Chemical Co. LTD	58
Shanghai Synmedia Chemical Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Suzhou Rovathin Foreign Trade Co.,Ltd	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- Spectrum

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)-(2094893-05-5)¹HNMR

2-Piperazinone, 1-(5-methyl-2-furanyl)-4-(1-oxo-2-propen-1-yl)- EN523 inhibit,EN-523,Inhibitor,non-catalytic,EN523,OTUB1 recruiter,EN 523,deubiquitinase,allosteric cysteine C23 4-Acryloyl-1-(5-methyl-2-furyl)piperazin-2-one 2094893-05-5