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Dizocilpine

CAS No.
77086-21-6
Chemical Name:
Dizocilpine
Synonyms
C13737;Dizocilpine;MK-801 (Dizocilpine);Dizocilpine (MK-801);Dizocilpine USP/EP/BP;Dizocilpine free base;Dizocilpine free base(MK801);(5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine;(5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene;5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)-
CBNumber:
CB81075436
Molecular Formula:
C16H15N
Molecular Weight:
221.3
MDL Number:
MFCD06412575
MOL File:
77086-21-6.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:30

Dizocilpine Properties

Melting point 68.5-69°
alpha 20589 +161.4° (c = 0.038 g/2 ml ethanol)
Boiling point 320.3±11.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
solubility Soluble in DMSO > 10 mM
form Powder
pka 7.96±0.40(Predicted)
FDA UNII 7PY8KH681I
EPA Substance Registry System 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- (77086-21-6)

SAFETY

Risk and Safety Statements

Hazardous Substances Data 77086-21-6(Hazardous Substances Data)

Dizocilpine Chemical Properties,Uses,Production

Uses

Neuroprotective.

Definition

ChEBI: Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).

380427-51-0
77086-21-6
Synthesis of Dizocilpine from 5H-Dibenzo[a,d]cyclohepten-5,10-imine-5-methanol, 10,11-dihydro-, (5S,10R)-
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View Lastest Price from Dizocilpine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dizocilpine pictures 2024-11-19 Dizocilpine
77086-21-6
US $30.00-87.00 / mg 99.97% 10g TargetMol Chemicals Inc.
Dizocilpine pictures 2020-02-06 Dizocilpine
77086-21-6
US $1.00 / KG 1KG 99%HPLC 100KG Career Henan Chemical Co
  • Dizocilpine pictures
  • Dizocilpine
    77086-21-6
  • US $30.00-87.00 / mg
  • 99.97%
  • TargetMol Chemicals Inc.
  • Dizocilpine pictures
  • Dizocilpine
    77086-21-6
  • US $1.00 / KG
  • 99%HPLC
  • Career Henan Chemical Co
(5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5α,10α-imine C13737 MK-801 (Dizocilpine) 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- Dizocilpine Dizocilpine free base(MK801) Dizocilpine USP/EP/BP Dizocilpine (MK-801) noncompetitive,MK 801,Dizocilpine,Ionotropic glutamate receptors,voltage,inhibit,MK801,hyperlocomotion,Inhibitor,iGluR,ambulation,neurotransmitter,anticonvulsant Dizocilpine free base (5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene 77086-21-6 Inhibitors