Bucainide
- CAS No.
- 51481-62-0
- Chemical Name:
- Bucainide
- Synonyms
- Bucainide;Bucainida;Bucainidum;Bucainide [inn];Bucainidum [inn-latin];Bucainida [inn-spanish];1-Hexyl-4-(N-isobutylbenzimidoyl)piperazin;1-Hexyl-4-(N-isobutylbenzimidoyl)piperazine;N-[(4-Hexyl-1-piperazinyl)phenylmethylene]-2-methyl-1-propanamine;1-Propanamine, N-((4-hexyl-1-piperazinyl)phenylmethylene)-2-methyl-
- CBNumber:
- CB81116555
- Molecular Formula:
- C21H35N3
- Molecular Weight:
- 329.52
- MDL Number:
- MFCD00867098
- MOL File:
- 51481-62-0.mol
| FDA UNII | F0D4M5RASG |
|---|
Bucainide Chemical Properties,Uses,Production
Originator
Bucainide maleate,ZYF Pharm Chemical
Uses
Cardiac depressant (anti-arrhythmic).
Manufacturing Process
To a solution of 13.6 g (0.08 mol) of N-hexylpiperazine and 8.1 g (11.2 ml), (0.08 mol) of triethylamine in 120 ml toluene, was added 15.6 g (0.08 mol) of N-isobutyl-benzimidoyl chloride over a period of 15 minutes. The reaction mixture was stirred at room temperature for a period of 2 hours. The triethylamine hydrochloride was filtered off and the filtrate concentrated under vacuum. The residual oily base was washed with 20 ml water, extracted with 50 ml ether and dried over anhydrous magnesium sulfate. The dry ethereal solution was then added to a solution of 18.6 g (0.16 mol) maleic acid in 800 ml ether to obtain the dimaleate salt. Two recrystallizations from ethanol yielded 22.5 g (50.2%) of N-[(4-hexyl-1-piperazinyl)phenylmethylene]-2- methyl-1-propanamine product, M.P. 175°-176°C.
Therapeutic Function
Antiarrhythmic
Bucainide Preparation Products And Raw materials
Bucainide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
