Enclomiphene
- CAS No.
- 15690-57-0
- Chemical Name:
- Enclomiphene
- Synonyms
- enclomiphene;Enclomifene;EncloMiphene-d4;trans-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethylethanamine;ici46476;RMI 16,289;(E)-Clomiphene;trans-clomifene;E-CloMiphene-d4;trans-clomiphene
- CBNumber:
- CB8128416
- Molecular Formula:
- C26H28ClNO
- Molecular Weight:
- 405.96
- MDL Number:
- MFCD08060098
- MOL File:
- 15690-57-0.mol
- MSDS File:
- SDS
| Melting point | 149.0-150.5° |
|---|---|
| Boiling point | 509.0±50.0 °C(Predicted) |
| Density | 1.104±0.06 g/cm3(Predicted) |
| pka | 9.60±0.25(Predicted) |
| FDA UNII | R6D2UI4FLS |
Enclomiphene price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C587015 | trans-Clomiphene | 15690-57-0 | 2.5mg | $195 | 2021-12-16 | Buy |
| TRC | C587015 | trans-Clomiphene | 15690-57-0 | 25mg | $1540 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005680 | ETHANAMINE, 2-[4-[(1E)-2-CHLORO-1,2-DIPHENYLETHENYL]PHENOXY]-N,N-DIETHYL 95.00% | 15690-57-0 | 5MG | $498.83 | 2021-12-16 | Buy |
Enclomiphene Chemical Properties,Uses,Production
Description
Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility.
Uses
trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility.
Definition
ChEBI: Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene.
Preparation
CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/
Biological Activity
Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer.
Mode of action
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion.
References
[1] SIMON HILL Richard Q Vijayaraman Arutchelvam. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.[J]. Idrugs, 2009, 12 2: 109-119.
[2] KATHERINE M RODRIGUEZ Larry I L Alexander W Pastuszak. Enclomiphene citrate for the treatment of secondary male hypogonadism.[J]. Expert Opinion on Pharmacotherapy, 2016, 17 11: 1561-1567. DOI:10.1080/14656566.2016.1204294.
[3] JOSHUA A EARL Edward D K. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.[J]. Expert Review of Endocrinology & Metabolism, 2019, 14 3: 157-165. DOI:10.1080/17446651.2019.1612239.
Enclomiphene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
View Lastest Price from Enclomiphene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-15 | Androxal(Enclomiphene) 25mg Tablets
15690-57-0
|
US $0.00-0.00 / Bottle | 1Bottle | 99% | 2000 | Shandong Huizhihan Supply Chain Co., Ltd | |
 |
2024-10-23 | Enclomiphene
15690-57-0
|
US $250.00-2000.00 / g | 1g | 99% | 10kg | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2024-09-25 | TRANS-CLOMIPHENE HCL
15690-57-0
|
US $0.00 / kg | 1kg | 99% HPLC | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd |
-
- Androxal(Enclomiphene) 25mg Tablets
15690-57-0
- US $0.00-0.00 / Bottle
- 99%
- Shandong Huizhihan Supply Chain Co., Ltd
-
- Enclomiphene
15690-57-0
- US $250.00-2000.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
-
- TRANS-CLOMIPHENE HCL
15690-57-0
- US $0.00 / kg
- 99% HPLC
- Wuhan Senwayer Century Chemical Co.,Ltd