IS-741 potassium
- CAS No.
- 141284-74-4
- Chemical Name:
- IS-741 potassium
- Synonyms
- IS-741 potassium;Cyclohexanecarboxamide, N-[2-[(ethylsulfonyl)amino]-5-(trifluoromethyl)-3-pyridinyl]-, potassium salt (1:1)
- CBNumber:
- CB813377665
- Molecular Formula:
- C15H20F3N3O3S.K
- Molecular Weight:
- 418.5
- MDL Number:
- MOL File:
- 141284-74-4.mol
| FDA UNII | E4SVV6H6A3 |
|---|
IS-741 potassium Chemical Properties,Uses,Production
Uses
Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site[1][2].
References
[1] Noriyuki Kaji, et al. Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa. J Vet Med Sci. 2023 Sep 21. DOI:10.1292/jvms.23-0257
[2] C Bassi. IS-741 (Ishihara Sangyo). Curr Opin Investig Drugs. 2001 Apr;2(4):510-2. PMID:11566008
[3] Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. DOI:10.1248/bpb.22.127
[4] Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9. DOI:10.1007/s00535-002-1081-8
IS-741 potassium Preparation Products And Raw materials
Raw materials
Preparation Products
IS-741 potassium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19939 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 26071 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from IS-741 potassium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | IS-741 potassium
141284-74-4
|
US $1520.00-1980.00 / mg | 10g | TargetMol Chemicals Inc. |
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- IS-741 potassium
141284-74-4
- US $1520.00-1980.00 / mg
- TargetMol Chemicals Inc.