BPC 157

BPC 157 Properties

Melting point	>232°C (dec.)
Boiling point	1802.9±65.0 °C(Predicted)
Density	1.366±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Methanol (Slightly), Water (Slightly)
pka	3.36±0.10(Predicted)
form	Solid
color	White to Off-White
Sequence	H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
Stability	Hygroscopic
InChIKey	HEEWEZGQMLZMFE-ANCKLJOMNA-N
FDA UNII	8ED8NXK95P

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P280-P305+P351+P338

BPC 157 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1719	BPC 157 trifluoroacetate salt ≥95% (HPLC)	137525-51-0	1MG	$204	2024-03-01	Buy
TRC	B676720	BPC157	137525-51-0	1mg	$95	2021-12-16	Buy
TRC	B676720	BPC157	137525-51-0	25mg	$695	2021-12-16	Buy
AK Scientific	0719AP	BPC157	137525-51-0	1g	$1117	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0009357	BPC-157 95.00%	137525-51-0	5MG	$499.3	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1719	1MG	$204	Buy
B676720	1mg	$95	Buy
B676720	25mg	$695	Buy
0719AP	1g	$1117	Buy
PEP0009357	5MG	$499.3	Buy

BPC 157 Chemical Properties,Uses,Production

Description

BPC 157 is not a steroid.It is a synthetic peptide derived from a protective protein and helps alleviate joint pain, injuries, and those looking to improve joint mobility. BPC-157 is often most used to treat stomach and intestinal conditions such as inflamed intestinal epithelium (leaky gut), eosinophilic esophagitis, and inflammatory bowel disease; however, its abilities to improve tpe 1 collagen and increase blood flow via angiogenesis means it is a powerful peptide for wound healing and overall regeneration following damage. Notably, BPC-157 aids in alleviating joint pain, old injuries and those looking to improve joint mobility.

Uses

Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, M.W. 1419, PL 14736) and wound healing, stable in human gastric juice and has no reported toxicity. BPC-157 can be used in conjunction with other therapies to enhance and increase your results.

benefits

There have been many positive effects noted by those who have experimented with the use of BPC-157 for issues including bone healing, ligament healing, general regenerative properties and more. We will list just a small few of the key health benefits here.
Potent anti-inflammatory
Possesses neuro-protective properties—specifically modulating the serotonergic and dopaminergic systems
Promotes angiogenesis and vasculogenesis
Accelerates wound healing (e.g. muscle, ligament, tendon, nerve)
Promotes cell survival under stress
Maintains GI mucosal integrity
Protects and prevents gastric ulcers
Improves digestive function (IBS)
Used in Inflammatory bowel disease (IBD) exacerbations/flares
Protects liver from toxic insults (alcohol, antibiotics, etc) and promotes healing
Repairs tissue; such as GIT, tendons, ligaments, brain, bone, etc
Effective treatment for Traumatic brain injury (TBI)
Protects and heals inflamed intestinal epithelium (Leaky Gut Syndrome)

Biological Activity

BPC 157 is a gut peptide and possesses free radical scavenging activity. This peptide stimulates nitric oxide synthase generation and therefore offers gastric cytoprotection. Unlike other peptides, BPC 157 is effective without a carrier. It participates in muscle healing and is used in the treatment of gastrocnemius muscle complex.
BPC 157 is a stable gastric pentadecapeptide that exhibit anti-ulcer and wounds/fistulas healing properties. BPC 157 reduces immediate and delayed damage induced brain trauma and improves nerve regeneration after transection. BPC 157 displays antianxiety and antidepressant effects. It appears that BPC 157 promotes proliferation, migration, and tube formation of human umbilical vein endothelial cells through activation of ERK1/2 phosphorylation.

Mechanism of action

BPC 157 has a direct therapeutic effect in rats after a stroke. It counteracted both early and delayed neural damage. In addition, BPC 157 promoted full functional recovery; this compound ameliorated the declines in several behavioral tasks: the Morris water maze, inclined beam-walking, and lateral push tests. BPC 157 treatment led to the upregulation of Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3, and Nos1 and the downregulation of Nos2 and Nfkb compared with untreated rats. The marked Egr1 and Vegfr2 upregulation suggests that BPC 157 has vascularisation properties, and this mechanism likely underlies its ability to modulate ischemia/reprofusion injury. The most interesting finding is the strong upregulation of Nos3, slight upregulation of Nos1, and suppression of Nos2 compared with control animals. These effects may potentially provide a novel therapeutic solution for stroke, imparting specific beneficial effects on the CNS (i.e., for reperfusion, the amelioration of neuronal damage and, thereby, recovery without memory, locomotor, and coordination disturbances, and the expression of the particular genes in the hippocampus). Notably, BPC 157 may scavenge reactive oxygen species due to its structure: it contains four carboxylic groups, and when they are reactivated (by glutathione or enzymes), the antioxidant activity is very high. In addition, because most tissues contain BPC 157, it can bind and inactivate reactive free radicals at crucial positions not reachable by other antioxidants[1-2].

Clinical Use

Therapeutically, the synthetically produced peptide BPC-157 is not currently approved for use as a human drug. It is an experimental compound that has been investigated for inflammatory bowel disease and soft tissue healing, although there is a concerning lack of published clinical trial data because studies appear to have been cancelled or stopped without any published conclusions.
Even though there are no studies or clinical trials that show BPC-157 is safe or effective in humans, some websites related to performance-enhancing drugs advertise that it can be injected or taken orally for bone and joint healing, stomach ulcers, organ damage, and a number of other purposes, including athletic performance enhancement. It is important to realize that these are unproven claims, and that the use of BPC-157 for these or any other reasons is not supported by medical literature or by any medical associations.
Other websites advertise BPC-157 as a “research chemical” that is “not for human use,” and yet, the same websites have suggestions for how someone could use it. Athletes are advised to never use a product that is marketed for “research only.”

Side effects

BPC-157 side effects (if any) are usually mild, especially when used at the proper dosage. Regardless, it is worth noting that research on BPC is still limited. We can however look to side effects associated with other peptides to hypothesize what we might need to look out for.
Flashes of very hot or cold temperature
Changes to appetite and/or weight
Dizziness
Fatigue
Headaches

Safety

BPC-157 is generally considered safe for use. As it is naturally found in gastric juices, it should be well tolerated by the body in theory. It is however important to note that human clinical trials are still limited and side effects, as above, have been reported. We cannot say for sure long-term use implications may be at this point. As with any supplement in this stage, we would advice ceasing use if any concerns to arise.
As far as tested athletes are concerned - BPC is not currently on the WADA banned list under the section naming “peptide hormones, growth factors, related substances, and mimetics” (as of October 2020). This means that natural bodybuilders and sportspeople might use it without risk of bans.

Dosage forms

BPC-157 comes in two different forms: oral capsules and an injectable form. As an oral capsule, BPC-157 is best suited for gut restoration and for addressing intestinal problems. On the other hand, BPC-157 injectable is the preferred route of administration for inflammation, muscle sprains, ligament damage, and pain.

References

[1] Vukojevi, Jaka , et al. "Pentadecapeptide BPC 157 and the central nervous system." Neural Regeneration Research 17.3(2022):6.
[2] Madzarac, Goran , et al. "Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications." Current Neuropharmacology 14.8(2016).

BPC 157 Preparation Products And Raw materials

Raw materials

Preparation Products

BPC 157 Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONTIDE BIOTECH CO.,LTD	+852-7026-8763 +85253358525	amy@healthtide-api.com	China	551	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210 +86-13129979210	sales@cellwh.com	China	376	58
Zhuzhou New Peptides Tech Co.,Ltd.	+86-18073326374 +86-18073326374	sales@goodpeptides.com	China	56	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12837	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	295	58
American HealthyMorph LLC	+8613363867578	13363867578@163.com	China	78	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2541	58

Supplier	Advantage
CONTIDE BIOTECH CO.,LTD	58
Cellmano Biotech Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Wuhan Cell Pharmaceutical Co., Ltd	58
Zhuzhou New Peptides Tech Co.,Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Apeloa production Co.,Limited	58
Hangzhou Hyper Chemicals Limited	58
American HealthyMorph LLC	58
Shanghai Longyu Biotechnology Co., Ltd.	58

View Lastest Price from BPC 157 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-18	BPC 157 137525-51-0	US $99.00-66.00 / kg	0.0010000000474974513kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2024-12-18	BPC 157 137525-51-0	US $10.00 / ASSAYS	1ASSAYS	99%	100kg	Dorne Chemical Technology co. LTD
2024-12-18	BPC 157 137525-51-0	US $36.00 / Box	5Box	99%	1000 boxes	Huaian Banting Trading Co., Ltd.

BPC 157
137525-51-0
US $99.00-66.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

BPC 157
137525-51-0
US $10.00 / ASSAYS
99%
Dorne Chemical Technology co. LTD

BPC 157
137525-51-0
US $36.00 / Box
99%
Huaian Banting Trading Co., Ltd.

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