BPC 157: Uses, Dosages, Benefits and Side Effects

Uses of BPC 157

Body Protection Compound 157 (BPC 157) is a peptide consisting of 15 amino acids. It is derived from the body's own proteins or can be chemically synthesised. BPC 157 has anti-inflammatory and wound-healing effects on a wide range of target tissues and organs, including muscles, tendons, ligaments and the gastrointestinal tract. It is also neuroprotective and has favourable benefits for central nervous system disorders. 

BPC 157 is used as a drug, food or dietary supplement. BPC 157 can be taken orally, topically or by injection when used as a therapeutic agent. BPC-157 is one of the only peptides that can survive in the acidic environment of the stomach, so oral treatment may be very effective. Moreover, oral BPC-157 has a low bioavailability and does not usually have a direct effect on tissues outside the gastrointestinal tract (e.g., tendons and nerves). However, animal studies have shown systemic effects with oral ingestion and caution is needed. However, BPC 157 is a therapeutic agent not approved by the FDA, which cites ‘risk of immunogenicity, peptide-related impurities, and limited safety-related information’ as reasons for banning BPC-157.

Dosages

The dosage of BPC 157 is dependent on a number of factors such as the type of disease, severity of the condition, age, gender and dosage form, so please consult your doctor before using to avoid serious adverse reactions.

In addition, experimental studies have shown that the effective oral dose in rats is 10 μg/kg, which is estimated to be equivalent to 1.6 μg/kg, or:

110 μg for a 150lb person

145 μg for a 200lb person

180 μg for a 250lb person

Benefits of BPC 157 supplement

The benefits of BPC 157 as a supplement or peptide therapy are shown in the following ways:

Promotes wound healing

Accelerates tissue regeneration

Reduces inflammation

Increases blood flow

Relieves joint pain

Enhances immune function

Reduces muscle weakness, debility and muscle damage

Reduces nerve damage and cerebral oedema

Side Effects

No significant serious adverse reactions have been reported with BPC 157. Common side effects include nausea, dizziness, hot flashes, blood pressure fluctuations, and hepatic and renal complications. Because there is insufficient evidence from clinical studies of BPC 157, its safety and long-term effects on humans cannot be determined.

References:

[1] S. ŠTRBE. Pentadecapeptide BPC 157 Counteracts the Adverse Effect of Lithium Overdose in Rats[J]. FASEB Journal, 2019. DOI:10.1096/fasebj.2019.33.1\_supplement.822.4.

[2] YOUNG-HOON JUNG. The anti-nociceptive effect of BPC-157 on the incisional pain model in rats[J]. Journal of Dental Anesthesia and Pain Medicine, 2022. DOI:10.17245/jdapm.2022.22.2.97.

[3] JAKŠA VUKOJEVIC. Pentadecapeptide BPC 157 and the central nervous system.[J]. Neural Regeneration Research, 2022, 17 3: 482-487. DOI:10.4103/1673-5374.320969.

[4] SVEN SEIWERTH. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.[J]. Frontiers in Pharmacology, 2021: 627533. DOI:10.3389/fphar.2021.627533.