3-AMINO-6-METHOXYPYRIDAZINE
- CAS No.
- 7252-84-8
- Chemical Name:
- 3-AMINO-6-METHOXYPYRIDAZINE
- Synonyms
- 6-methoxypyridazin-3-amine;3-PyridazinaMine, 6-Methoxy-;EOS-62222;NSC 73703;Netarsudil Impurity 12;6-Methoxy-3-pyridazinamine;3-AMINO-6-METHOXYPYRIDAZINE;6-Amino-3-methoxypyridazine;3-Methoxy-6-aminopyridazine;6-Methoxy-pyridazin-3-ylamine
- CBNumber:
- CB8134491
- Molecular Formula:
- C5H7N3O
- Molecular Weight:
- 125.13
- MDL Number:
- MFCD01646127
- MOL File:
- 7252-84-8.mol
- MSDS File:
- SDS
| Melting point | 108-109℃ |
|---|---|
| Boiling point | 353.5±22.0 °C(Predicted) |
| Density | 1.224 |
| storage temp. | 2-8°C(protect from light) |
| form | Solid |
| pka | 5.84±0.10(Predicted) |
| InChI | InChI=1S/C5H7N3O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3,(H2,6,7) |
| InChIKey | YPWBPONDYDVMLX-UHFFFAOYSA-N |
| SMILES | C1(N)=NN=C(OC)C=C1 |
| FDA UNII | N3H9A46C5H |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| HS Code | 2933998090 |
3-AMINO-6-METHOXYPYRIDAZINE price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A612073 | 3-Amino-6-methoxypyridazine | 7252-84-8 | 100mg | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-2N | 3-Amino-6-methoxypyridazine | 7252-84-8 | 1g | $76 | 2021-12-16 | Buy |
| ChemScene | CS-0019296 | 3-Amino-6-methoxypyridazine 99.91% | 7252-84-8 | 10g | $79 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-2N | 3-Amino-6-methoxypyridazine | 7252-84-8 | 250mg | $40 | 2021-12-16 | Buy |
| Matrix Scientific | 072012 | 3-Amino-6-methoxypyridazine 95+% | 7252-84-8 | 1g | $41 | 2021-12-16 | Buy |
3-AMINO-6-METHOXYPYRIDAZINE Chemical Properties,Uses,Production
Description
3-amino-6-methoxypyridazine: a critical pharmaceutical intermediate.
It can be used for pyridopyrimidine compounds with remarkable biological activity or medicines, such as the anticancer drug Ruugeli, which can be used for treating indications such as pain caused by endometriosis, uterine fibroids and advanced prostate cancer. At present, many reports on the preparation method of the compound exist, and various process impurities such as 3-amino-6-chloropyridazine, 3-amino-6-hydroxypyridazine, 3-chloro-6-hydroxypyridazine, 3-dichloropyridazine, 3, 6-dimethoxypyridazine, 3-amino-6-methoxypyridazine, 3-aminopyridazine and the like are often introduced in the process of the conventional synthesis process.
Uses
3-Amino-6-methoxypyridazine is an organic reagent that can be used as a key intermediate in the preparation of Relugoli.
Synthesis
A total of 3.40 g. (0.026 mol) 3-amino-6-chloropyridazine was placed in a Carius tube with a solution of sodium methoxide in methanol [prepared from 0.61 g. (0.027 mol) of clean sodium metal and 50 ml. of methanol], and the Carius tube was sealed. The tube was placed in a Carius furnace for 20 hours. After the tube was cooled and opened, the contents were removed, and the light brown solid was filtered off. The filtrate was evaporated to dryness at room temperature under an air jet. The resulting orange-brown crystalline solid was dissolved in a 60:40 petroleum ether-chloroform solution, treated with activated charcoal and filtered. There was obtained, upon. Talline solid fromn-amyl chloride accompanied by treat- 3 ment with activated charcoal yielded 0.51 g. of a white, crystalline solid 3-amino-6-methoxypyridazine melting at 103-105 ℃.
3-AMINO-6-METHOXYPYRIDAZINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 998 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9215 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
View Lastest Price from 3-AMINO-6-METHOXYPYRIDAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-20 | 3-Amino-6-methoxypyridazine
7252-84-8
|
US $45.00 / kg | 1kg | 0.99 | 10 tons | Suzhou Nordica Biopharma CO.,LTD | |
 |
2024-09-20 | Relugolix Impurity 5
7252-84-8
|
US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2024-04-09 | 3-AMINO-6-METHOXYPYRIDAZINE
7252-84-8
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3-Amino-6-methoxypyridazine
7252-84-8
- US $45.00 / kg
- 0.99
- Suzhou Nordica Biopharma CO.,LTD
-
- Relugolix Impurity 5
7252-84-8
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- 3-AMINO-6-METHOXYPYRIDAZINE
7252-84-8
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd