α- Erythroidine
- CAS No.
- 466-80-8
- Chemical Name:
- α- Erythroidine
- Synonyms
- a-Erythroidine;1,2,6,7-Tetradehydro-12,17-dihydro-3β-methoxy-16(15H)-oxaerythrinan-15-one;1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one, 2,6,8,9,9a,10-hexahydro-2-methoxy-, (2R,9aS,13bS)-
- CBNumber:
- CB81470765
- Molecular Formula:
- C16H19NO3
- Molecular Weight:
- 273.33
- MDL Number:
- MOL File:
- 466-80-8.mol
| Melting point | 58-60° |
|---|---|
| alpha | D27 +136° (c = 0.5 in water) |
| FDA UNII | 0M56M9D8T6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
α- Erythroidine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S284459 | 12-METHOXY-4,4A,5,6,12,13-HEXAHYDRO-8H-PYRANO(4'',3'':3,4)PYRIDO(2,1-I)INDOL-2-ONE AldrichCPR | 466-80-8 | 25MG | $110 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | PXT0002177 | ALPHA-ERYTHROIDINE 95.00% | 466-80-8 | 5MG | $497.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0300164 | 12-METHOXY-4,4A,5,6,12,13-HEXAHYDRO-8H-PYRANO(4',3':3,4)PYRIDO(2,1-I)INDOL-2-ONE 95.00% | 466-80-8 | 5MG | $505.82 | 2021-12-16 | Buy |
α- Erythroidine Chemical Properties,Uses,Production
Purification Methods
Recrystallise -erythroidine from pentane. It is best prepared freshly from the more stable hydrochloride. The hydrochloride (1.3g) in H2O (20mL) is basified with NaHCO3 to pH ~8 and extracted with *C6H6 (6 x 10mL). The combined extracts are evaporated to a small volume and refrigerated. The free base separates as white hygroscopic crystals m 52-55o, which are recrystallised from pentane. Although stable in solution, the crystals turn brown on exposure to air. -Erythroidine hydrochloride is best purified by dissolving 10g in H2O (100mL), adjusting the pH to 8 with aqueous NaHCO3, extracting with *C6H6 (4 x 20mL), evaporating to 20mL, passing through activated Al2O3 and eluting with *C6H6. The eluate is evaporated to a small volume and the crystals are collected, dissolved in EtOH and dry HCl gas passed through to give the pure hydrochloride. When recrystallised from EtOH, it has m 226-228o(dec), and [ ] D 32 +118o (c 0.5, H2O). It has max 224nm ( 35,500); compare with -erythroidine hydrochloride below. [Boelkeleide & Grundon J Am Chem Soc 75 2563 1953, Boekeleide & Morrison J Am Chem Soc 80 3905 1958, abs config: Hill & Shearer J Org Chem 2 7 3342 1955, Beilstein 27 III/IV 3569.]