AF-2
- CAS No.
- 3688-53-7
- Chemical Name:
- AF-2
- Synonyms
- ff;AF-2;tofuron;NSC 44973;furylamide;furylfuramide;af2(preservative);Furylfuramide (AF-2);alpha-2-furyl-5-nitro-2-furanacrylamid;2-(furyl)-3-(5-nitro-2-furyl)acrylamide
- CBNumber:
- CB8179544
- Molecular Formula:
- C11H8N2O5
- Molecular Weight:
- 248.19
- MDL Number:
- MFCD00869231
- MOL File:
- 3688-53-7.mol
| Melting point | >152°C (dec.) |
|---|---|
| Boiling point | 391.26°C (rough estimate) |
| Density | 1.4153 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Amber Vial, Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 14.00±0.50(Predicted) |
| color | Orange to Dark Red |
| Stability | Stable. Hydrophobic. |
| FDA UNII | 054NR2135Y |
| IARC | 2B (Vol. 31, Sup 7) 1987 |
| EPA Substance Registry System | Furylfuramide (3688-53-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H351 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| HS Code | 2932990090 |
AF-2 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F864270 | Furylfuramide | 3688-53-7 | 100mg | $1455 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb364181 | AF-2 > 95% | 3688-53-7 | 1mg | $353.6 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0297006 | FURYLFURAMIDE 95.00% | 3688-53-7 | 5MG | $502.29 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb364181 | AF-2 > 95% | 3688-53-7 | 5mg | $688.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb364181 | AF-2 > 95% | 3688-53-7 | 10mg | $884 | 2021-12-16 | Buy |
AF-2 Chemical Properties,Uses,Production
Chemical Properties
orange crystalline solid
Uses
Furylfuramide is a synthetic nitrofuran derivative widely used as a food additive and was investigated for possible carcinogenicity.
Definition
ChEBI: A member of the class of acrylamides that is acrylamide which is substituted at positions 2 and 3 by 2-furyl and 5-nitro-2-furyl groups, respectively (the trans isomer). Formerly used as a food preservative, it was withdrawn from the marke following suspicions of carcenogenicity.
General Description
Bright orange crystals.
Air & Water Reactions
Hydrophobic. Insoluble in water.
Reactivity Profile
A nitrated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-(2-FURYL)-3-(5-NITRO-2-FURYL)ACRYLAMIDE emits toxic fumes.
Fire Hazard
Flash point data for 2-(2-FURYL)-3-(5-NITRO-2-FURYL)ACRYLAMIDE are not available but 2-(2-FURYL)-3-(5-NITRO-2-FURYL)ACRYLAMIDE is probably combustible.
Toxicology
AF-2 was legally approved for use in Japan in 1965 and was added to soybean curd (tofu), ham, sausage, fish ham, fish sausage, and fish paste (kamaboko). The safety-testing data on which the compound was approved were those obtained for acute and chronic toxicity for two years and reproductive potential for four generations using mice and rats. At the time, no attention was paid to mutagenicity. In 1973, AF-2 was proved to be mutagenic in various microbial test systems. The mutagenicity of this food additive strongly suggested its carcinogenicity and the risk of its use as a food additive. Within a year or two after the discovery of its mutagenicity, the actual carcinogenicity of this chemical was demonstrated in animal studies.The mechanism of carcinogenesis is not yet clear, but a close relation between carcinogens and mutagens has been demonstrated. AF-2 was the first example of compound that was shown to be a carcinogen. The fact that AF-2 was discovered first to be mutagenic proved the value of mutagenicity testing as a screening method for carcinogens.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and teratogenic data. Poison by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
AF-2 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94717 | 76 |
| Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 15085 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56068 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-021-61109150 | sales@tcisct.com | China | 31163 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | alan.chow@synzest.com | China | 9471 | 58 |