8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
![8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Structure](CAS/GIF/85547-22-4.gif)
- CAS No.
- 85547-22-4
- Chemical Name:
- 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
- Synonyms
- Apatamine;AAPTAMINE;6]naphtyridine;9-Dimethoxy-1H-benzo[de][1;8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE;6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(;8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE;1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
- CBNumber:
- CB8243320
- Molecular Formula:
- C13H12N2O2
- Molecular Weight:
- 228.25
- MDL Number:
- MFCD01662128
- MOL File:
- 85547-22-4.mol
- MSDS File:
- SDS
| storage temp. | 4°C, protect from light |
|---|---|
| solubility | DMSO: soluble,Ethanol: soluble |
| form | Solid |
| color | White to yellow |
| FDA UNII | FGW9D01COE |
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24297 | Aaptamine | 85547-22-4 | 1mg | $283 | 2021-12-16 | Buy |
| Cayman Chemical | 24297 | Aaptamine | 85547-22-4 | 500μg | $149 | 2021-12-16 | Buy |
| TRC | A164268 | Aaptamine | 85547-22-4 | 1mg | $170 | 2021-12-16 | Buy |
| ChemScene | CS-0032464 | Aaptamine ≥98.0% | 85547-22-4 | 1mg | $305 | 2021-12-16 | Buy |
| AK Scientific | 8722CA | Aaptamine | 85547-22-4 | 1mg | $482 | 2021-12-16 | Buy |
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Chemical Properties,Uses,Production
Uses
Aaptamine is a spongean alkaloid that can activate the p21 promoter in the absence of p53 and can function as a proteasome inhibitor.
Synthesis Reference(s)
The Journal of Organic Chemistry, 52, p. 616, 1987 DOI: 10.1021/jo00380a024
Tetrahedron Letters, 31, p. 569, 1990 DOI: 10.1016/0040-4039(90)87037-Z
in vivo
Aaptamine (5-100 μg; intrathecal injection; single dose) has an analgesic effect in a rat model of chronic constriction injury (CCI)-induced peripheral neuropathy[7].
| Animal Model: | Chronic constriction injury treated adult male Wistar rats (250-285 g)[7] |
| Dosage: | 5, 30 and 100 μg |
| Administration: | Intrathecal injection; single dose |
| Result: | Showed different durations of analgesic effects on CCI-induced nociception. The 5 μg, 30 μg, and 100 μg doses presented analgesic durations of 90, 150, and 150 minutes respectively. However, the variance in the group administered with 100 μg of aaptamine was the largest, and the rats presented some abnormal motor behavior. |
IC 50
AChE: 0.23 μg/mL (IC50); BChE: 1.38 μg/mL (IC50)
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8144 | 55 |