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PF-01367338

PF-01367338 structure

CAS No.: 459868-92-9

Chemical Name:: PF-01367338

Synonyms: CS-47;AG14699;Rubraca;AG-014699;PF-01367338;Rucaparib(AG-01);Rucaparib D4 HCl;AG014699 phosphate;Rucaparib phosphate;PF-01367338/AG14699

CBNumber:: CB82515928

Molecular Formula:: C19H21FN3O5P

Molecular Weight:: 421.37

MDL Number:: MFCD17010269

MOL File:: 459868-92-9.mol

MSDS File:: SDS

Last updated:2023-10-10 16:35:53

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PF-01367338 Properties

Melting point	>173°C (dec.)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 25 mg/ml).
form	Yellow solid.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII	H3M9955244
NCI Dictionary of Cancer Terms	AG014699
NCI Drug Dictionary	Rubraca

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS02
Signal word	Warning
Hazard statements	H315-H319-H226
Precautionary statements	P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235

PF-01367338 price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11570	Rucaparib (phosphate) ≥98%	459868-92-9	1mg	$32	2024-03-01	Buy
Cayman Chemical	11570	Rucaparib (phosphate) ≥98%	459868-92-9	5mg	$139	2024-03-01	Buy
Cayman Chemical	11570	Rucaparib (phosphate) ≥98%	459868-92-9	10mg	$243	2024-03-01	Buy
TRC	A425500	AG14699	459868-92-9	10mg	$140	2021-12-16	Buy
TRC	A425500	AG14699	459868-92-9	5mg	$90	2021-12-16	Buy

Product number	Packaging	Price	Buy
11570	1mg	$32	Buy
11570	5mg	$139	Buy
11570	10mg	$243	Buy
A425500	10mg	$140	Buy
A425500	5mg	$90	Buy

PF-01367338 Chemical Properties,Uses,Production

Description

Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1?Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2?Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3?Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4?Ameliorates the cardiotoxicity of doxorubicin.5?Recently approved for human use by the FDA.

Uses

PARP inhibitor oncolytic

References

1) Thomas?et al.?(2007),?Preclinical selection of a n novel poly(ADP-ribose) polymerase inhibitor for clinical trial; Mol. Cancer Ther.,?6?945 2) Drew?et al.?(2011),?Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2; J. Natl. Cancer Inst.,?103?334 3) Ihnen?et al.?(2013),?Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer; Mol. Cancer Ther.,?12?1002 4) Plummer?et al.?(2013),?A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation; Cancer Chemother. Pharmacol.,?71?1191 5) Ali?et al.?(2011),?The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice; Mol. Cancer Ther.,?10?2320

PF-01367338 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-01367338 Suppliers

Global( 216)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12830	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29792	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	8441	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29871	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	281	58

Supplier	Advantage
Hebei Mujin Biotechnology Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Biochempartner	58
Hangzhou Cyanochem Co., Ltd.	58

View Lastest Price from PF-01367338 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-02-14	PF-01367338 459868-92-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2024-10-17	Rucaparib 459868-92-9	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Weibang Biotechnology Co., Ltd
2022-10-01	Rucaparib phosphate;PF01367338 phosphate 459868-92-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

PF-01367338
459868-92-9
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

Rucaparib
459868-92-9
US $0.00-0.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Rucaparib phosphate;PF01367338 phosphate
459868-92-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

PF-01367338 Spectrum

PF-01367338(459868-92-9)¹HNMR

459868-92-9(PF-01367338)Related Search:

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NU1025 1H-BenziMidazole, 4-fluoro-2-Methyl-1-(1-Methylethyl)-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzaldehyde

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AG-014699 AG-014699;PF-01367338 PF-01367338 AG14699 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate Rucaparib (AG-014699 , PF-01367338) Rucaparib phosphate AG-014699 (Rucaparib) 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(MethylaMino)Methyl]phenyl]-, phosphate (1:1) PF-01367338/AG14699 Rucaparib(AG-014699) 8-fluoro-5-(4-((methylamino)methyl)phenyl)-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one phosphoric acid 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate Rucaparib(AG-014699) AG 014699 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one phosphate Rucaparib ( PF-01367338) Rucaparib phosphate AG-014699 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate Rucaparib(AG-01) 8-fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-onephosphate 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one pho PF01367338 phosphate Rucaparib (AG-014699,PF-01367338) phosphate Rucaparib (AG-014699) phosphate AG014699;RUCAPARIB PHOSPHATE Rucaparib (phosphate)(AG-014699,PF-01367338) Rucaparib phosphate salt Rucaparib phosphate (AG-14699, PF-01367338) CS-47 AG 014699 - PF 01367338 | Rucaparib AG-014447 (as free base) AG-14699 (as phosphate salt) AG-14699 (AS PHOSPHATE SALT); AG-014447 (AS FREE BASE); RUCAPARIB; PF-01367338; AG014699; AG 014699 phosphate AG014699 phosphate AG-014699 phosphate RUCAPARIB PHOSPHATE;AG014699 PHOSPHATE;PF01367338 PHOSPHATE;AG 014699 PHOSPHATE;PF 01367338 PHOSPHATE;AG-014699 PHOSPHATE;PF-01367338 PHOSPHATE AG14699 (AS PHOSPHATE SALT); AG 14699; AG-14699; AG014447 (AS FREE BASE); AG-014447; AG 014447; PF01367338; PF-01367338; PF 01367338; RUCAPARIB; RUBRACA; Rubraca PF-01367338 USP/EP/BP Rucaparib D4 HCl TIANFUCHEM--PF-01367338 Rucaparib Phosphate, 10 mM in DMSO 459868-92-9 C19H21FN3O5P C19H18FN3OH3PO4 C19H18FN3OH3O4P Inhibitors Inhibitor Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals