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Unii-950o97nupo

Unii-950o97nupo Structure
Unii-950o97nupo structure
CAS No.
377727-87-2
Chemical Name:
Unii-950o97nupo
Synonyms
MK3814;CS-672;MK 3814;MK-3814;Preladent;SCH-420814;Preladenant;Unii-950o97nupo;Preladenant (MK-3814;Sch 420814 Preladenant
CBNumber:
CB82520825
Molecular Formula:
C25H29N9O3
Molecular Weight:
503.56
MDL Number:
MFCD17167056
MOL File:
377727-87-2.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22
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Unii-950o97nupo Properties

Density 1.47±0.1 g/cm3(Predicted)
storage temp. -20°
solubility Soluble in DMSO (up to 5 mg/ml with warming).
form solid
pka 6.42±0.40(Predicted)
color Beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
FDA UNII 950O97NUPO
NCI Drug Dictionary preladenant

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H319-H372-H410-H361
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P273-P391-P501-P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501
NFPA 704
0
2 0

Unii-950o97nupo price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22210 Preladenant ≥98% 377727-87-2 1mg $86 2024-03-01 Buy
Cayman Chemical 22210 Preladenant ≥98% 377727-87-2 5mg $356 2024-03-01 Buy
Cayman Chemical 22210 Preladenant ≥98% 377727-87-2 10mg $629 2024-03-01 Buy
Cayman Chemical 22210 Preladenant ≥98% 377727-87-2 25mg $1152 2024-03-01 Buy
TRC P712600 Preladenant 377727-87-2 50mg $3520 2021-12-16 Buy
Product number Packaging Price Buy
22210 1mg $86 Buy
22210 5mg $356 Buy
22210 10mg $629 Buy
22210 25mg $1152 Buy
P712600 50mg $3520 Buy

Unii-950o97nupo Chemical Properties,Uses,Production

Description

Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively). It is selective for A2A receptors over A1, A2B, and A3 receptors (Kis = >1,000, >1,700, and >1,000 nM, respectively) as well as a panel of 59 receptors, enzymes, and ion channels. Preladenant inhibits adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively) induced by the A2A receptor agonist CGS 21680 . It inhibits catalepsy induced by haloperidol in rats by 77 and 70% after 1 and 4 hours, respectively, when administered at a dose of 1 mg/kg. Preladenant also increases the efficacy of L-DOPA when used in combination with eltoprazine in a 6-OHDA rat lesion model of Parkinson’s disease dyskinesia.

Uses

A potent and selective antagonist at the adenosine A2A receptor. It is being researched as a potential treatment for Parkinson''s disease.

target

adenosine A2A receptor

References

1)?Hodgson?et al.?(2009), Characterization of the potent and selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimodin-5-amine] in rat models of movement disorders and depression;?J.Pharmacol.Exp.Ther.?330294 2)?Hodgson?et al.?(2010), Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders;?Exp.Neurol.?225384 3)?Pinna?et al.?(2016), Antidyskinetic effect of A2A and 5HT1A/B receptor ligands in two animal models of Parkinson’s disease;?Mov.Disord.?31501 4)?Beavis?et al.?(2013), Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors;?Proc.Natl.Acad.Sci USA.?11014711 5)?Hatfield and Sitkovsky (2016), A2A adenosine receptor antagonist to weaken the hypoxia-HIF-1a driven immunosuppression and improve immunotherapies of cancer;?Curr.Opin.Pharmacol.?2990 6)?Ohta?et al.?(2016), A metabolic immune checkpoint: adenosine in the tumor microenvironment;?Front.Immunol.?71 7)?NCT03099161

Unii-950o97nupo Preparation Products And Raw materials

Raw materials

Preparation Products

Unii-950o97nupo Suppliers

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 17453 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chengdu Feibo Pharm Technology Co., Ltd 		+86 028-84641798 15982321820 abby@arkpharm.com China 10924 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9314 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Accela ChemBio Inc. 		58
BOC Sciences 		58
Chengdu Feibo Pharm Technology Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from Unii-950o97nupo manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Preladenant pictures 2024-11-19 Preladenant
377727-87-2
 US $34.00-77.00 / mg 98.18% 10g TargetMol Chemicals Inc.
Preladenant pictures 2021-07-13 Preladenant
377727-87-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Preladenant pictures 2021-07-09 Preladenant
377727-87-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Preladenant pictures
  • Preladenant
    377727-87-2
  • US $34.00-77.00 / mg
  • 98.18%
  • TargetMol Chemicals Inc.
  • Preladenant pictures
  • Preladenant
    377727-87-2
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Preladenant pictures
  • Preladenant
    377727-87-2
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Unii-950o97nupo Spectrum

Unii-950o97nupo(377727-87-2)1HNMR

377727-87-2(Unii-950o97nupo)Related Search:

Geldanamycin Imatinib mesylate ZM 336372 17-AAG
2-(2-Furanyl)-7-[2-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-aMine 2-Furan-2-yl-7-(2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethyl)-7,9a-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-ylaMine 7H-Pyrazolo(4,3-E)(1,2,4)triazolo(1,5-C)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)- Preladenant SCH-420814 Unii-950o97nupo 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1,2,4 Sch 420814 Preladenant 5-Amino-2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine 2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1 Preladenant (SCH 420814) MK 3814 MK3814 MK-3814 SCH420814; SCH-420814; SCH 420814; MK-3814; MK 3814; MK3814; PRELADENANT Preladent CS-672 SCH-420814;?SCH 420814;?SCH420814 4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine TIANFUCHEM--Unii-950o97nupo Preladenant (MK-3814 Preladenant SCH-420814 SCH-420814 377727-87-2 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Amines