SGI-1776
- CAS No.
- 1025065-69-3
- Chemical Name:
- SGI-1776
- Synonyms
- CS-504;I-1776;SGI-1776;S I-1776;SGI-1776, >=98%;SGI-1776;SGI1776;I-1776 free base;SGI-1776 free base;SGI-1776 USP/EP/BP;Pim-Kinase Inhibitor IX
- CBNumber:
- CB82561495
- Molecular Formula:
- C20H22F3N5O
- Molecular Weight:
- 405.42
- MDL Number:
- MFCD16659064
- MOL File:
- 1025065-69-3.mol
| Density | 1.37 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH |
| pka | 9.22±0.10(Predicted) |
| form | Solid |
| color | White to yellow |
| FDA UNII | 72AUA0603W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
SGI-1776 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16423 | SGI-1776 ≥98% | 1025065-69-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16423 | SGI-1776 ≥98% | 1025065-69-3 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 16423 | SGI-1776 ≥98% | 1025065-69-3 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 16423 | SGI-1776 ≥98% | 1025065-69-3 | 50mg | $759 | 2024-03-01 | Buy |
| Usbiological | 474186 | SGI-1776 | 1025065-69-3 | 100mg | $1677 | 2021-12-16 | Buy |
SGI-1776 Chemical Properties,Uses,Production
Uses
A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively.
Uses
SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.
Definition
ChEBI: N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-6-imidazo[1,2-b]pyridazinamine is a member of imidazoles.
Biological Activity
sgi-1776 free base, n-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent atp-competitive inhibitor of the serine/threonine family of pim kinase, an enzyme regulating cell survival. through extensive biomedical characterization, sgi-1776 exhibits specificity to the three isoforms of the pim family, including pim-1, pim-2, and pim-3. according to preliminary results from studies treating prostate cancer cells, sgi-1776 dose-dependently reduces phosphorylation of known pim kinase substrates involved in cell cycle progression and apotosis (p21cip1/waf1 and bad), compromises overall cell viability by inducing g1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (mdr1) protein based taxane-refractory prostate cancer cell line.shannon m. mumenthaler, patricia y.b. ng, amanda hodge, davide bearss, gregory berk, sarath kanekal, sanjeev redkar, pietro taverna, davide b. agus, and anjali jain. pharmacological inhibition of pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. mol cancer ther. 2009; 8(10): 2882-2893lisa s. chen, s anjeev redkar, david bearss, william g. wierda and varsha gandhi. pim kinase inhibitor, sgi-1776, induces apoptosis in cll lymphocytes. blood. 2009; 114(19): 4150-4157
in vivo
SGI-1776 free base (75, 200 mg/kg, p.o.) shows potent and sustained antitumor activity in a dose dependent manner in MV-4-11 xenografts in mice[4].
target
Pim1
SGI-1776 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22854 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 |
View Lastest Price from SGI-1776 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | SGI-1776
1025065-69-3
|
US $98.00-320.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | SGI-1776
1025065-69-3
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-13 | SGI-1776
1025065-69-3
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |