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ChemicalBook >> CAS DataBase List >> SGI-1776

SGI-1776

$28 - $3136.5
Product name: SGI-1776
CAS: 1025065-69-3
MF: C20H22F3N5O
MW: 405.42
EINECS:200-258-5
MDL Number:MFCD16659064
Synonyms:N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776;SGI-1776;SGI-1776 free base;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776, >=98%;SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776 FREE BASE;SGI1776

Price28 Properties Safety Information Description

28 prices

Selected condition：

Brand

Adipogen Life Sciences
AK Scientific
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Medical Isotopes, Inc.
TRC
Usbiological

Package

10mg
25mg
50mg
250mg
1000mg
1unit
1mg
10mM(in 1mL DMSO)
5mg
100mg

ManufacturerAdipogen Life Sciences
Product numberSYN-1193-M001
Product descriptionSGI-1776 ≥95%
Packaging1mg
Price$86
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1193-M100
Product descriptionSGI-1776 ≥95%
Packaging100mg
Price$1188
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product numberSYN1193
Product descriptionSGI-1776
Packaging100mg
Price$1120
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4192
Product descriptionSGI-1776freebase
Packaging1unit
Price$28
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4192
Product descriptionSGI-1776freebase
Packaging5mg
Price$90
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4192
Product descriptionSGI-1776freebase
Packaging10mM(in 1mL DMSO)
Price$100
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4192
Product descriptionSGI-1776freebase
Packaging10mg
Price$170
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4192
Product descriptionSGI-1776freebase
Packaging50mg
Price$410
Updated2021-12-16
Buy

ManufacturerArctom
Product numberCFN60248
Product descriptionSGI-1776freebase ≥98%
Packaging10mg
Price$358
Updated2021-12-16
Buy

ManufacturerAxon Medchem
Product numberAxon1633
Product descriptionSGI1776freebase 98%
Packaging25mg
Price$357.5
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb181025
Product descriptionSGI-1776 >98%
Packaging100mg
Price$838.1
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb181025
Product descriptionSGI-1776 >98%
Packaging250mg
Price$1504.5
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb181025
Product descriptionSGI-1776 >98%
Packaging1000mg
Price$3136.5
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number16423
Product descriptionSGI-1776 ≥98%
Packaging1mg
Price$32
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number16423
Product descriptionSGI-1776 ≥98%
Packaging5mg
Price$139
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number16423
Product descriptionSGI-1776 ≥98%
Packaging10mg
Price$214
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Adipogen Life Sciences	SYN-1193-M001	SGI-1776 ≥95%	1mg	$86	2021-12-16	Buy
Adipogen Life Sciences	SYN-1193-M100	SGI-1776 ≥95%	100mg	$1188	2021-12-16	Buy
AK Scientific	SYN1193	SGI-1776	100mg	$1120	2021-12-16	Buy
ApexBio Technology	A4192	SGI-1776freebase	1unit	$28	2021-12-16	Buy
ApexBio Technology	A4192	SGI-1776freebase	5mg	$90	2021-12-16	Buy
ApexBio Technology	A4192	SGI-1776freebase	10mM(in 1mL DMSO)	$100	2021-12-16	Buy
ApexBio Technology	A4192	SGI-1776freebase	10mg	$170	2021-12-16	Buy
ApexBio Technology	A4192	SGI-1776freebase	50mg	$410	2021-12-16	Buy
Arctom	CFN60248	SGI-1776freebase ≥98%	10mg	$358	2021-12-16	Buy
Axon Medchem	Axon1633	SGI1776freebase 98%	25mg	$357.5	2021-12-16	Buy
Biorbyt Ltd	orb181025	SGI-1776 >98%	100mg	$838.1	2021-12-16	Buy
Biorbyt Ltd	orb181025	SGI-1776 >98%	250mg	$1504.5	2021-12-16	Buy
Biorbyt Ltd	orb181025	SGI-1776 >98%	1000mg	$3136.5	2021-12-16	Buy
Cayman Chemical	16423	SGI-1776 ≥98%	1mg	$32	2024-03-01	Buy
Cayman Chemical	16423	SGI-1776 ≥98%	5mg	$139	2024-03-01	Buy
Cayman Chemical	16423	SGI-1776 ≥98%	10mg	$214	2024-03-01	Buy

Next Last

Properties

Density :1.37
storage temp. :Store at -20°C
solubility :≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka :9.22±0.10(Predicted)
form :Solid
color :White to yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little effect on several other kinases, including cell cycle kinases. SGI-1776 induces apoptosis in lymphocytes from patients with chronic or acute lymphocytic leukemia but not in those from healthy donors. At 10 μM, it reduces STAT3 phosphorylation without reducing STAT3 expression in cancer cells, and this correlates with inhibition of cell proliferation. SGI-1776 also enhances the activity of sunitinib against renal cell carcinoma and resensitizes chemoresistant prostate cancer cells to taxanes.

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Suppliers and manufacturers

career henan chemical co

$1.00 /1g
SGI-1776 CAS:1025065-69-3

TargetMol Chemicals Inc.

$98.00 /5mg
SGI-1776 CAS:1025065-69-3

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