(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
![(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione price.](/CAS/GIF/438190-29-5.gif)
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- $44 - $1949.9
- Product name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
- CAS: 438190-29-5
- MF: C11H6F3NO2S
- MW: 273.23
- EINECS:200-256-5
- MDL Number:MFCD01152003
- Synonyms:(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione;TCS PIM-1 4a;SMI-4a;(Z)-5-(3-(trifluoroMethyl)benzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-[[3-(trifluoromethyl)phenyl]methylene]-, (5Z)-;TCS PIM-1 4a, >=98%;(5E)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione;(Z)-SMI-4a
35 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 5mg
- 2x10mg
- 100mg
- 2x50mg
- 250mg
- 500mg
- 1000mg
- 1mg
- 50mg
- 1G
- 2.5G
- 10mg
- 5G
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1113-M001
- Product descriptionSMI-4a ≥95%
- Packaging1mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1113
- Product descriptionSMI-4a
- Packaging50mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0135588
- Product description(5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00%
- Packaging1G
- Price$692.46
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0135588
- Product description(5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00%
- Packaging2.5G
- Price$932.6
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0135588
- Product description(5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00%
- Packaging5G
- Price$1114.58
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4193
- Product descriptionSMI-4a
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4193
- Product descriptionSMI-4a
- Packaging10mM(in 1mL DMSO)
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4193
- Product descriptionSMI-4a
- Packaging50mg
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1923
- Product descriptionSMI4a-Piminhibitor4a 98%
- Packaging2x10mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1923
- Product descriptionSMI4a-Piminhibitor4a 98%
- Packaging50mg
- Price$302.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1923
- Product descriptionSMI4a-Piminhibitor4a 98%
- Packaging2x50mg
- Price$484
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181324
- Product descriptionSMI 4a >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181324
- Product descriptionSMI 4a >98%
- Packaging250mg
- Price$1030.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181324
- Product descriptionSMI 4a >98%
- Packaging1000mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11029
- Product descriptionSMI-4a ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11029
- Product descriptionSMI-4a ≥98%
- Packaging5mg
- Price$64
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1113-M001 | SMI-4a ≥95% | 1mg | $54 | 2021-12-16 | Buy |
| AK Scientific | SYN1113 | SMI-4a | 50mg | $340 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0135588 | (5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00% | 1G | $692.46 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0135588 | (5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00% | 2.5G | $932.6 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0135588 | (5Z)-5-[3-(TRIFLUOROMETHYL)BENZYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE 95.00% | 5G | $1114.58 | 2021-12-16 | Buy |
| ApexBio Technology | A4193 | SMI-4a | 10mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A4193 | SMI-4a | 10mM(in 1mL DMSO) | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A4193 | SMI-4a | 50mg | $265 | 2021-12-16 | Buy |
| Axon Medchem | Axon1923 | SMI4a-Piminhibitor4a 98% | 2x10mg | $132 | 2021-12-16 | Buy |
| Axon Medchem | Axon1923 | SMI4a-Piminhibitor4a 98% | 50mg | $302.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon1923 | SMI4a-Piminhibitor4a 98% | 2x50mg | $484 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181324 | SMI 4a >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181324 | SMI 4a >98% | 250mg | $1030.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181324 | SMI 4a >98% | 1000mg | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11029 | SMI-4a ≥98% | 5mg | $64 | 2024-03-01 | Buy |
Properties
Density :1.530±0.06 g/cm3(Predicted)
storage temp. :Desiccate at +4°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.38±0.20(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
storage temp. :Desiccate at +4°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.38±0.20(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
The serine/threonine Pim kinases have been suggested to promote the activity of the rapamycin-sensitive mammalian target of rapamycin (mTORC1), which regulates cell growth and survival. Pim kinases are overexpressed in solid cancers and hematologic malignancies, and as such have become targets of small molecule inhibitors to prevent the progression of various cancers. SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. SIM-4a kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM). Incubation of precursor T-cell lymphoblastic leukemia/lymphoma cells with 10 μM SMI-4a induces G1 phase cell-cycle arrest, dose-dependent induction of p27Kip1, apoptosis through the mitochondrial pathway, and inhibition of the mTORC1 pathway. In immunodeficient mice carrying subcutaneous pre–T-LBL tumors, treatment twice daily with 60 mg/kg SMI-4a causes a significant delay in the tumor growth.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Hubei xin bonus chemical co. LTD
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
![(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione](https://img.chemicalbook.com/ProductImageEN/2019-9/small/d330a174-c4e0-491b-b584-ffde058fc907.png){kind=small}