Welcome to chemicalbook!
400-158-6606
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> A-674563

A-674563

A-674563 price.
  • $49 - $5541
  • Product name: A-674563
  • CAS: 552325-73-2
  • MF: C22H22N4O
  • MW: 358.44
  • EINECS:
  • MDL Number:MFCD11840461
  • Synonyms:A-674563;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine;A-674563 /A674563;(2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563;A-674563 (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563 /A674563;A-674563;A 674563; A674563;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
32 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Usbiological
Package
  • 500μg
  • 500ug
  • 1mg
  • 2MG
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • 5g
  • 250mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3680-M005
  • Product descriptionA-674563(freebase) ≥98%(HPLC)
  • Packaging5mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1110-M001
  • Product descriptionA-674563hydrochloride ≥95%
  • Packaging1mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1110
  • Product descriptionA-674563HCl
  • Packaging10mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001241
  • Product descriptionA-674563 95.00%
  • Packaging2MG
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001241
  • Product descriptionA-674563 95.00%
  • Packaging5MG
  • Price$498.93
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8616
  • Product descriptionA-674563
  • Packaging5mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8616
  • Product descriptionA-674563
  • Packaging10mM(in 1mL DMSO)
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8616
  • Product descriptionA-674563
  • Packaging10mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8616
  • Product descriptionA-674563
  • Packaging50mg
  • Price$630
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8616
  • Product descriptionA-674563
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60355
  • Product descriptionA-674563
  • Packaging5mg
  • Price$338
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18715
  • Product descriptionA-674563 ≥95%
  • Packaging500μg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18715
  • Product descriptionA-674563 ≥95%
  • Packaging1mg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18715
  • Product descriptionA-674563 ≥95%
  • Packaging5mg
  • Price$333
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18715
  • Product descriptionA-674563 ≥95%
  • Packaging10mg
  • Price$570
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM150660
  • Product description(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine 98%
  • Packaging100mg
  • Price$982
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3680-M005 A-674563(freebase) ≥98%(HPLC) 5mg $145 2021-12-16 Buy
Adipogen Life Sciences SYN-1110-M001 A-674563hydrochloride ≥95% 1mg $189 2021-12-16 Buy
AK Scientific SYN1110 A-674563HCl 10mg $470 2021-12-16 Buy
American Custom Chemicals Corporation INB0001241 A-674563 95.00% 2MG $300 2021-12-16 Buy
American Custom Chemicals Corporation INB0001241 A-674563 95.00% 5MG $498.93 2021-12-16 Buy
ApexBio Technology A8616 A-674563 5mg $140 2021-12-16 Buy
ApexBio Technology A8616 A-674563 10mM(in 1mL DMSO) $154 2021-12-16 Buy
ApexBio Technology A8616 A-674563 10mg $210 2021-12-16 Buy
ApexBio Technology A8616 A-674563 50mg $630 2021-12-16 Buy
ApexBio Technology A8616 A-674563 100mg $980 2021-12-16 Buy
Arctom CFN60355 A-674563 5mg $338 2021-12-16 Buy
Cayman Chemical 18715 A-674563 ≥95% 500μg $49 2024-03-01 Buy
Cayman Chemical 18715 A-674563 ≥95% 1mg $92 2024-03-01 Buy
Cayman Chemical 18715 A-674563 ≥95% 5mg $333 2024-03-01 Buy
Cayman Chemical 18715 A-674563 ≥95% 10mg $570 2024-03-01 Buy
Chemenu CM150660 (S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine 98% 100mg $982 2021-12-16 Buy

Properties

Boiling point :624.4±55.0 °C(Predicted)
Density :1.229
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥23.8 mg/mL in H2O; ≥4.9 mg/mL in DMSO
form :solid
pka :13.43±0.40(Predicted)
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4 μM. In vivo, 40 mg/kg/day A-674563 in combination with 15 mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model.

Related product price