4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
- $28 - $4469.3
- Product name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
- CAS: 937174-76-0
- MF: C21H27N7O3
- MW: 425.48
- EINECS:
- MDL Number:MFCD14105605
- Synonyms:4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol;(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridi;(R)-4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-(PIPERIDIN-3-YLMETHOXY)-1H-IMI;4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol;4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol GSK 690693;4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol;GSK690693, >=98%;(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyr
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Brand
- Activate Scientific
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1unit
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 250mg
- 1g
- ManufacturerActivate Scientific
- Product numberAS10002
- Product descriptionGSK690693 95+% ee
- Packaging1mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS10002
- Product descriptionGSK690693 95+% ee
- Packaging5mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3628-M005
- Product descriptionGSK690693 ≥95%
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1043
- Product descriptionGSK-690693
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging1mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging5mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging10mg
- Price$101
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging50mg
- Price$302
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging100mg
- Price$495
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging250mg
- Price$991
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA111141
- Product description(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+%
- Packaging1g
- Price$2824
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000687
- Product descriptionGSK-690693 95.00%
- Packaging25MG
- Price$1386
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000687
- Product descriptionGSK-690693 95.00%
- Packaging5MG
- Price$822.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000687
- Product descriptionGSK-690693 95.00%
- Packaging1MG
- Price$191.1
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5072
- Product descriptionGSK690693
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA5072
- Product descriptionGSK690693
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Activate Scientific | AS10002 | GSK690693 95+% ee | 1mg | $87 | 2021-12-16 | Buy |
Activate Scientific | AS10002 | GSK690693 95+% ee | 5mg | $149 | 2021-12-16 | Buy |
Adipogen Life Sciences | AG-CR1-3628-M005 | GSK690693 ≥95% | 5mg | $95 | 2021-12-16 | Buy |
AK Scientific | SYN1043 | GSK-690693 | 10mg | $185 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 1mg | $40 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 5mg | $67 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 10mg | $101 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 50mg | $302 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 100mg | $495 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 250mg | $991 | 2021-12-16 | Buy |
Ambeed | A111141 | (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol 98+% | 1g | $2824 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000687 | GSK-690693 95.00% | 25MG | $1386 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000687 | GSK-690693 95.00% | 5MG | $822.8 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0000687 | GSK-690693 95.00% | 1MG | $191.1 | 2021-12-16 | Buy |
ApexBio Technology | A5072 | GSK690693 | 100mg | $600 | 2021-12-16 | Buy |
ApexBio Technology | A5072 | GSK690693 | 25mg | $250 | 2021-12-16 | Buy |
Properties
Boiling point :683.8±65.0 °C(Predicted)
Density :1.41
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
pka :13.11±0.29(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Density :1.41
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution)
pka :13.11±0.29(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Safety Information
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Signal word: | Danger | ||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
GSK690693 is an ATP-competitive, pan-Akt kinase inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively. It also inhibits other members of the AGC kinase family, including AMPK, DAPK3, PAKs, PKA, PKC, PKG, and PrkX (IC50 values range from 2-81 nM). By preventing the phosphorylation of downstream Akt substrates, GSK690693 has been shown to inhibit proliferation and to induce apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice.Related product price
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