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TRICHOSTATIN A

TRICHOSTATIN A structure

CAS No.: 58880-19-6

Chemical Name:: TRICHOSTATIN A

Synonyms: TSA;A 300I;CS-210;CS-2704;trichostatin;richostatinA;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)

CBNumber:: CB8257301

Molecular Formula:: C17H22N2O3

Molecular Weight:: 302.37

MDL Number:: MFCD03848392

MOL File:: 58880-19-6.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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TRICHOSTATIN A Properties

Melting point	140-143℃
alpha	D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density	1.139
refractive index	136 ° (C=0.3, MeOH)
storage temp.	-20°C
solubility	ethanol: 1 mg/mL
pka	8.93±0.23(Predicted)
form	Off-white lyophilized solid
color	Tan
Merck	14,9649
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	ZWGICMNKJBUOHG-RCXLNATQSA-N
FDA UNII	3X2S926L3Z
NCI Drug Dictionary	trichostatin A

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H317-H319-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38-43

Safety Statements

26-36

RIDADR

NA 1993 / PGIII

WGK Germany

RTECS

MI5215000

HS Code

29280000

NFPA 704

	0
3		0

TRICHOSTATIN A price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T1952	Trichostatin A, Ready Made Solution 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.	58880-19-6	200μL	$87.6	2024-03-01	Buy
Sigma-Aldrich	647925	Trichostatin A	58880-19-6	1mg	$289	2024-03-01	Buy
TCI Chemical	T2477	Trichostatin A >98.0%(HPLC)	58880-19-6	10mg	$551	2024-03-01	Buy
TCI Chemical	T2477	Trichostatin A >98.0%(HPLC)	58880-19-6	50mg	$1901	2024-03-01	Buy
Cayman Chemical	89730	Trichostatin A ≥98%	58880-19-6	500μg	$56	2024-03-01	Buy

Product number	Packaging	Price	Buy
T1952	200μL	$87.6	Buy
647925	1mg	$289	Buy
T2477	10mg	$551	Buy
T2477	50mg	$1901	Buy
89730	500μg	$56	Buy

TRICHOSTATIN A Chemical Properties,Uses,Production

Description

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Chemical Properties

Solid

Uses

Trichostatin A, ready-made solution has been used:

as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
to treat cells for the HDAC inhibition experiments

Uses

Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity

Uses

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

Definition

ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.

General Description

Trichostatin A is a compound of primary hydroxamic acid.

Biological Activity

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

storage

-20°C (desiccate)

References

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Preparation Products And Raw materials

Raw materials

Preparation Products

TRICHOSTATIN A Suppliers

Global( 230)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9214	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Chongqing Chemdad Co., Ltd	58
Hebei shuoxi biotechnology co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from TRICHOSTATIN A manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Trichostatin A 58880-19-6	US $86.00-197.00 / mg		98.3%	10g	TargetMol Chemicals Inc.
2024-04-02	Trichostatin A 58880-19-6	US $10.00-100.00 / kg	1kg	99%	5000 Metric Ton/Month	Wuhan Xinhao Biotechnology Co., Ltd
2021-03-17	trichostatin A 58880-19-6	US $0.00 / KG	1g	99.9%	1 ton	Hebei shuoxi biotechnology co. LTD

Trichostatin A
58880-19-6
US $86.00-197.00 / mg
98.3%
TargetMol Chemicals Inc.

Trichostatin A
58880-19-6
US $10.00-100.00 / kg
99%
Wuhan Xinhao Biotechnology Co., Ltd

trichostatin A
58880-19-6
US $0.00 / KG
99.9%
Hebei shuoxi biotechnology co. LTD

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7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID Trichostatin A from Streptomyces platensis [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide TRICHOSTATIN A TRICHOSTATIN A, STREPTOMYCES SPECIES Trichostatin A, Streptomyces sp. 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- TRICHOSTATIN A FROM STREPTOMYCES SP (2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid (2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (R)-Trichostatin A A 300I (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide Trichostatin A, Ready Made Solution Trichostatin A Vetec(TM) reagent grade, from Streptomyces sp., >=98% (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE Trichostatin A (TSA) (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide trichostatin TRICHOSTATIN A USP/EP/BP richostatinA isolated from species of the bacterial genus Streptomyces. CS-210 CS-2704 Trichostatin A, 98%, from Streptomyces sp. TSA Histone deacetylases,inhibit,Inhibitor,HDAC,Trichostatin A Trichostatin A solution(10mM/L) (+)-Trichostatin A Trichostatin A (R-isomer) 58880-19-6 5880-19-6 Gene Regulation and Expression DNA-RNA Transcription Regulators BioChemical Cell Signaling and Neuroscience Cell Biology Inhibitors antibiotic API Anti Cancer Research Inhibitor