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TRICHOSTATIN A

CAS No.
58880-19-6
Chemical Name:
TRICHOSTATIN A
Synonyms
TSA;A 300I;CS-210;CS-2704;trichostatin;richostatinA;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
CBNumber:
CB8257301
Molecular Formula:
C17H22N2O3
Molecular Weight:
302.37
MDL Number:
MFCD03848392
MOL File:
58880-19-6.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

TRICHOSTATIN A Properties

Melting point 140-143℃
alpha D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density 1.139
refractive index 136 ° (C=0.3, MeOH)
storage temp. -20°C
solubility ethanol: 1 mg/mL
pka 8.93±0.23(Predicted)
form Off-white lyophilized solid
color Tan
Merck 14,9649
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey ZWGICMNKJBUOHG-RCXLNATQSA-N
FDA UNII 3X2S926L3Z
NCI Drug Dictionary trichostatin A

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H317-H319-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-43
Safety Statements  26-36
RIDADR  NA 1993 / PGIII
WGK Germany  3
RTECS  MI5215000
HS Code  29280000
NFPA 704
0
3 0

TRICHOSTATIN A price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T1952 Trichostatin A, Ready Made Solution 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp. 58880-19-6 200μL $87.6 2024-03-01 Buy
Sigma-Aldrich 647925 Trichostatin A 58880-19-6 1mg $289 2024-03-01 Buy
TCI Chemical T2477 Trichostatin A >98.0%(HPLC) 58880-19-6 10mg $551 2024-03-01 Buy
TCI Chemical T2477 Trichostatin A >98.0%(HPLC) 58880-19-6 50mg $1901 2024-03-01 Buy
Cayman Chemical 89730 Trichostatin A ≥98% 58880-19-6 500μg $56 2024-03-01 Buy
Product number Packaging Price Buy
T1952 200μL $87.6 Buy
647925 1mg $289 Buy
T2477 10mg $551 Buy
T2477 50mg $1901 Buy
89730 500μg $56 Buy

TRICHOSTATIN A Chemical Properties,Uses,Production

Description

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.

Chemical Properties

Solid

Uses

Trichostatin A, ready-made solution has been used:

  • as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
  • to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
  • to treat cells for the HDAC inhibition experiments

Uses

Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity

Uses

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

Definition

ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.

General Description

Trichostatin A is a compound of primary hydroxamic acid.

Biological Activity

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

storage

-20°C (desiccate)

References

1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 230)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 18751 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714 FandaChem@Gmail.com China 9080 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32956 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Hebei shuoxi biotechnology co. LTD
+8613081092107 CHINA 964 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
Richest Group Ltd
18017061086 oled@richest-group.com CHINA 5600 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

View Lastest Price from TRICHOSTATIN A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trichostatin A pictures 2024-11-19 Trichostatin A
58880-19-6
US $86.00-197.00 / mg 98.3% 10g TargetMol Chemicals Inc.
Trichostatin A pictures 2024-04-02 Trichostatin A
58880-19-6
US $10.00-100.00 / kg 1kg 99% 5000 Metric Ton/Month Wuhan Xinhao Biotechnology Co., Ltd
trichostatin A pictures 2021-03-17 trichostatin A
58880-19-6
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD
  • Trichostatin A pictures
  • Trichostatin A
    58880-19-6
  • US $86.00-197.00 / mg
  • 98.3%
  • TargetMol Chemicals Inc.
  • Trichostatin A pictures
  • Trichostatin A
    58880-19-6
  • US $10.00-100.00 / kg
  • 99%
  • Wuhan Xinhao Biotechnology Co., Ltd
  • trichostatin A pictures
  • trichostatin A
    58880-19-6
  • US $0.00 / KG
  • 99.9%
  • Hebei shuoxi biotechnology co. LTD
7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID 4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID Trichostatin A from Streptomyces platensis [r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide 7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide TRICHOSTATIN A TRICHOSTATIN A, STREPTOMYCES SPECIES Trichostatin A, Streptomyces sp. 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- TRICHOSTATIN A FROM STREPTOMYCES SP (2E,4E,6R)-4,6-Dimethyl-7-[4-(dimethylamino)phenyl]-7-oxo-2,4-heptadienehydroximic acid (2E,4E,6R)-4,6-Dimethyl-7-oxo-7-[4-(dimethylamino)phenyl]-2,4-heptadienehydroximic acid Trichostatin A,TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide (R)-Trichostatin A A 300I (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide Trichostatin A, Ready Made Solution Trichostatin A Vetec(TM) reagent grade, from Streptomyces sp., >=98% (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE Trichostatin A (TSA) (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide trichostatin TRICHOSTATIN A USP/EP/BP richostatinA isolated from species of the bacterial genus Streptomyces. CS-210 CS-2704 Trichostatin A, 98%, from Streptomyces sp. TSA Histone deacetylases,inhibit,Inhibitor,HDAC,Trichostatin A Trichostatin A solution(10mM/L) (+)-Trichostatin A Trichostatin A (R-isomer) 58880-19-6 5880-19-6 Gene Regulation and Expression DNA-RNA Transcription Regulators BioChemical Cell Signaling and Neuroscience Cell Biology Inhibitors antibiotic API Anti Cancer Research Inhibitor