Diphenylphosphinic Chloride
- CAS No.
- 1499-21-4
- Chemical Name:
- Diphenylphosphinic Chloride
- Synonyms
- DPPC;DIPHENYLPHOSPHINIC CHLORIDE;DPP-CL;Ph2POCl;phosphinic chL;Diphenylphoshinic;CHLORODIPHIOSPHINE OXIDE;DIPHENYLPHOSHINIC CHLORIDE;Diphenylphosphinic chlorid;DIPHENYLPHOSPHINYL CHLORIDE
- CBNumber:
- CB8273899
- Molecular Formula:
- C12H10ClOP
- Molecular Weight:
- 236.63
- MDL Number:
- MFCD00002077
- MOL File:
- 1499-21-4.mol
- MSDS File:
- SDS
| Melting point | 20°C |
|---|---|
| Boiling point | 222 °C/16 mmHg (lit.) |
| Density | 1.24 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 79 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, methanol |
| form | Liquid |
| Specific Gravity | 1.24 |
| color | Clear colorless to yellow |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| BRN | 975191 |
| CAS DataBase Reference | 1499-21-4(CAS DataBase Reference) |
| FDA UNII | 5GP30GY04V |
| NIST Chemistry Reference | Diphenylphosphinic chloride(1499-21-4) |
| UNSPSC Code | 12352002 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H314 | |||||||||
| Precautionary statements | P210-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C,F | |||||||||
| Risk Statements | 10-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2920 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| Hazard Note | Flammable/Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
Diphenylphosphinic Chloride price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 10g | $75.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 230235 | Diphenylphosphinic chloride 98% | 1499-21-4 | 50g | $296 | 2024-03-01 | Buy |
| TCI Chemical | C1415 | Diphenylphosphinic Chloride >98.0%(GC)(T) | 1499-21-4 | 25g | $121 | 2024-03-01 | Buy |
| Alfa Aesar | A11721 | Diphenylphosphinic chloride, 97+% | 1499-21-4 | 5g | $36.65 | 2024-03-01 | Buy |
| Alfa Aesar | A11721 | Diphenylphosphinic chloride, 97+% | 1499-21-4 | 25g | $118.65 | 2024-03-01 | Buy |
Diphenylphosphinic Chloride Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid
Uses
Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.
Application
Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.
reaction suitability
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
Synthesis
To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.
Diphenylphosphinic Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHANGZHOU HARVECHEM LTD | +86-0519-88784888 +8613906120163 | inquiry@harvechem.com | China | 271 | 58 |
| XINXIANG RUNYU MATERIAL CO., LTD. | +86-13592593621; +8613592593621 | sales@runvmat.com | China | 399 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29871 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
View Lastest Price from Diphenylphosphinic Chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-14 | Diphenylphosphinic Chloride
1499-21-4
|
US $50.00 / kg | 1kg | 99% | 5000kg/week | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-02-14 | Diphenylphosphinic chloride, 98%
1499-21-4
|
US $20.00 / KG | 1KG | 98% | 200tons/ year | Speranza Chemical Co., Ltd. | |
 |
2025-02-14 | Diphenylphosphinyl chloride
1499-21-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- Diphenylphosphinic Chloride
1499-21-4
- US $50.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Diphenylphosphinic chloride, 98%
1499-21-4
- US $20.00 / KG
- 98%
- Speranza Chemical Co., Ltd.
-
- Diphenylphosphinyl chloride
1499-21-4
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
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