CA-224
- CAS No.
- 883561-04-4
- Chemical Name:
- CA-224
- Synonyms
- CA-224;CA 224; CA224;[1,1'-Biphenyl]-4-carboxamide, N-[2-(1H-indol-3-yl)ethyl]-N-methyl-
- CBNumber:
- CB83038501
- Molecular Formula:
- C24H22N2O
- Molecular Weight:
- 354.44
- MDL Number:
- MOL File:
- 883561-04-4.mol
CA-224 Chemical Properties,Uses,Production
Description
CA-224 is potent CDK4 inhibitor, is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro. CA-224 blocks the growth of cancer cells at G0/ G1 phase of the cell cycle. CA-224 also blocks the cell cycle at G2/M phase, which is explained by the fact that it inhibits tubulin polymerization. Additionally, CA-224 acts as an enhancer of depolymerization for taxol-stabilized tubulin. CA-224 selectively induces apoptosis of SV40 large Tantigen. transformed cells and significantly reduces colony formation efficiency, in a dose-dependent manner, of lung cancer cells. The promising efficacy of CA-224 in human xenograft models as well as its excellent therapeutic window indicates its potential for clinical development.
CA-224 Preparation Products And Raw materials
Raw materials
Preparation Products
CA-224 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |
| Supplier | Advantage |
|---|---|
| AdooQ BioScience, LLC | 58 |
| Absin Bioscience Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |