VLX600
- CAS No.
- 327031-55-0
- Chemical Name:
- VLX600
- Synonyms
- Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone;6-methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole;6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine;iron,HCT116,Autophagy,glycolytic,VLX 600,colon,chelator,cancer,OXPHOS,VLX600,Mitochondrial Metabolism,proliferation,VLX-600,Inhibitor,oxidative phosphorylation,inhibit
- CBNumber:
- CB83152766
- Molecular Formula:
- C17H15N7
- Molecular Weight:
- 317.36
- MDL Number:
- MFCD01305422
- MOL File:
- 327031-55-0.mol
| Boiling point | 590.9±58.0 °C(Predicted) |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C,unstable in solution, ready to use. |
| solubility | ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 7.53±0.70(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | YZO6DG19MG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
VLX600 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17192 | VLX600 ≥95% | 327031-55-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17192 | VLX600 ≥95% | 327031-55-0 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17192 | VLX600 ≥95% | 327031-55-0 | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 17192 | VLX600 ≥95% | 327031-55-0 | 25mg | $397 | 2024-03-01 | Buy |
| TRC | V757175 | VLX600 | 327031-55-0 | 1mg | $45 | 2021-12-16 | Buy |
VLX600 Chemical Properties,Uses,Production
Description
VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 μM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells. VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.
Uses
VLX600 is a compound showing cytotoxicity against cancer cells. Selective towards malignant cells and necrosis inductor in colon cancer cells.
References
zhang x, frykns m, hernlund e, et al. induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. nat commun. 2014;5:3295.
VLX600 Preparation Products And Raw materials
Raw materials
Preparation Products
VLX600 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4566 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31553 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2988 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7296 | 58 |
