ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
- CAS No.
- 21085-72-3
- Chemical Name:
- ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER
- Synonyms
- (2R,3R,4S,5S,6S)-2-BroMo-6-(Methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate;Bromo-2,3,4-tri-O-acetyl-α-d-glucopyranuronic Acid Methyl Ester;Methyl acetobromo-α-D-glucuronate;METHYL ACETOBROMO-ALPHA-D-GLUCURONATE;acetobromo-α-d-glucuronic acid methyl ester;EOS-61715;Acetobromo-aL;Einecs 244-203-4;ucuronicacidmethyL;Methyl α-Acetobromoglucuronate
- CBNumber:
- CB8396406
- Molecular Formula:
- C13H17BrO9
- Molecular Weight:
- 397.17
- MDL Number:
- MFCD00061613
- MOL File:
- 21085-72-3.mol
- MSDS File:
- SDS
Melting point | 80-110 °C(lit.) |
---|---|
Boiling point | 388.6±42.0 °C(Predicted) |
Density | 1.52 |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), Dichlorometha |
form | Crystalline Powder or Solid |
color | White to gray |
BRN | 96281 |
Stability | Moisture and Temperature Sensitive |
InChIKey | BCDVKFMSIQGEHB-CIQUZCHMSA-N |
CAS DataBase Reference | 21085-72-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P271-P280 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
F | 3-8-10-21 |
Hazard Note | Irritant/Store Cold under -20oC |
HS Code | 29189900 |
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A8292 | Acetobromo-α-D-glucuronic acid methyl ester ≥93% | 21085-72-3 | 1g | $264 | 2024-03-01 | Buy |
Sigma-Aldrich | A8292 | Acetobromo-α-D-glucuronic acid methyl ester ≥93% | 21085-72-3 | 5g | $903 | 2024-03-01 | Buy |
Usbiological | A0200-89 | Acetobromo-a-D-glucuronic Acid, Methyl Ester | 21085-72-3 | 2g | $403 | 2021-12-16 | Buy |
TRC | A162000 | Acetobromo-α-D-glucuronicAcidMethylEster(contains2%CaCO3) | 21085-72-3 | 5g | $275 | 2021-12-16 | Buy |
Biosynth Carbosynth | MB31644 | 1-Bromo-2,3,4-tri-O-acetyl-a-D-glucuronide methyl ester | 21085-72-3 | 5G | $300 | 2021-12-16 | Buy |
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Chemical Properties,Uses,Production
Uses
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of HMR1098-S-glucuronide methyl ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of water-soluble glucuronide derivatives of Camptothecin, which is used for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Acetobromo-α-D-glucuronic acid methyl ester is used for the synthesis of glucuronide prodrug compounds of Janus kinase (JAK) inhibitor tofacitinib, which could be cleaved by β-glucuronidase enzymes such as those produced by the microbiome in the gastrointestinal tract, thereby increasing levels of tofacitinib at the site of gastrointestinal inflammation and limiting the systemic exposure of tofacitinib when treating localized inflammatory diseases.
Chemical Properties
White Crystalline Solid
Uses
Antitumor agent
ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 802 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
Jinan Samuel Pharmaceutical CO., Ltd | 0531-88821801 15192360884 | 605818151@qq.com | CHINA | 124 | 58 |
Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
Related articles
- Uses of Acetobromo-α-D-glucuronic acid methyl ester
- The IUPAC name of acetobromo-α-D-glucuronic acid methyl ester (C13H17BrO9) is methyl (2S,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-bro....
- Dec 11,2019
View Lastest Price from ACETOBROMO-ALPHA-D-GLUCURONIC ACID METHYL ESTER manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-22 | Acetobromo-a-D-glucuronic acid methyl ester
21085-72-3
|
US $0.00 / G | 1G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2022-02-19 | Acetobromo-alpha-d-glucuronic acid methyl ester
21085-72-3
|
US $0.00 / KG | 1KG | 98.4% | 100 tons | Honest Joy Holdings Limited
|
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2020-03-26 | 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronide methyl ester
21085-72-3
|
US $0.00 / g/bag | 25g/bag | 97%HPLC | MG-KG | GlycoPharm.LLC |
- Acetobromo-a-D-glucuronic acid methyl ester
21085-72-3
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- Acetobromo-alpha-d-glucuronic acid methyl ester
21085-72-3
- US $0.00 / KG
- 98.4%
- Honest Joy Holdings Limited
- 1-Bromo-2,3,4-tri-O-acetyl-α-D-glucuronide methyl ester
21085-72-3
- US $0.00 / g/bag
- 97%HPLC
- GlycoPharm.LLC
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