2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE
![2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE Structure](CAS/GIF/284464-77-3.gif)
- CAS No.
- 284464-77-3
- Chemical Name:
- 2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE
- Synonyms
- BM 567;1-[2-(cyclohexylamino)-5-nitrophenyl]sulfonyl-3-pentylurea;2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE;Benzenesulfonamide, 2-(cyclohexylamino)-5-nitro-N-[(pentylamino)carbonyl]-
- CBNumber:
- CB8404606
- Molecular Formula:
- C18H28N4O5S
- Molecular Weight:
- 412.5
- MDL Number:
- MFCD08062219
- MOL File:
- 284464-77-3.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≤10mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| form | crystalline solid |
| FDA UNII | 80Q1UI084N |
2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10155 | BM 567 | 284464-77-3 | 1000μg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 10155 | BM 567 | 284464-77-3 | 5000μg | $264 | 2024-03-01 | Buy |
| Cayman Chemical | 10155 | BM 567 | 284464-77-3 | 10000μg | $468 | 2024-03-01 | Buy |
| ApexBio Technology | C3695 | BM567 | 284464-77-3 | 10mg | $532 | 2021-12-16 | Buy |
| ApexBio Technology | C3695 | BM567 | 284464-77-3 | 5mg | $299 | 2021-12-16 | Buy |
2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE Chemical Properties,Uses,Production
Definition
ChEBI: BM 567 is a sulfonamide and a member of benzenes.
Biological Activity
bm 567 is acting as an inhibitor of thromboxane a2 (txa2) synthase and an antagonist of the tp receptor.thromboxane a2 (txa2), a potent thrombogenic and vasoconstrictor eicosanoid, is produced in large quantities by activated platelets. txa2 has been reported as a causal factor in the onset of stroke and myocardial infarction.
in vitro
bm 567 was identified as a dual acting antithrombogenic agent, acting as an inhibitor of thromboxane a2 (txa2) synthase and an antagonist of the tp receptor, the g protein-coupled receptor mediating txa2 activity in platelets and vascular smooth muscle. bm 567 antagonized the vascular smooth muscle tp receptor with an ic50 value of 1.1 nm. bm 567 was also able to inhibit platelet tx synthase with an ic50 value of 12 nm. in addition, by comparing crystallographic and electronic properties of bm567 and terbogrel, two compounds with dual action (txra and txsi), two essential anchoring identified: sulfonyl and nitro group for bm567 and carboxylate and pyridine nitrogen for terbogrel [1].
IC 50
1.1 nm for txa2 receptor antagonism
References
[1] michaux, c. ,rolin, s.,dogné, j.m., et al. structure determination and comparison of bm567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism, and thromboxane synthase inhibition. bioorganic & medicinal chemistry letters 11, 1019-1022 (2001).
2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-(CYCLOHEXYLAMINO)-5-NITRO-N-[(PENTYLAMINO)CARBONYL]-BENZENESULFONAMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| HUNAN CHEMFISH SCIENTIFIC CO.,LTD | 0731-85567275 18932438858 | sales@chemfish.com | China | 8356 | 58 |
| Xibao Biotechnology (Shanghai) Co., Ltd. | 13761246140 | 58642714@qq.com | China | 415 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19689 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 6813 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| Shaanxi Istare Biotechnology Co., Ltd. | 18682931470 | 2142355700@qq.com | China | 4255 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6251 | 58 |