ChemicalBook >> CAS DataBase List >>Fusidine
Fusidine
- CAS No.
- 6990-06-3
- Chemical Name:
- Fusidine
- Synonyms
- FUSIDIC ACID;Fusidinic acid;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;Fusidic acid CRS;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;sq16603;ramycin;Fuzidin;Flucidin
- CBNumber:
- CB8431174
- Molecular Formula:
- C31H48O6
- Molecular Weight:
- 516.72
- MDL Number:
- MFCD00865135
- MOL File:
- 6990-06-3.mol
- MSDS File:
- SDS
Last updated:2024-11-19 23:02:33
| Melting point | 190-192°C |
|---|---|
| alpha | D20 -9° (chloroform) |
| Boiling point | 521.49°C (rough estimate) |
| Density | 1.0389 (rough estimate) |
| vapor pressure | 0-0Pa at 25℃ |
| refractive index | 1.4890 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent) |
| pka | pK: 5.35 in water |
| form | Solid |
| color | White to Off-White |
| optical activity | -920 (c 1, CHCl3) |
| Water Solubility | 2.376-525000μg/L at 25℃ |
| λmax | 204nm(H2O)(lit.) |
| Merck | 14,4317 |
| Stability | Hygroscopic |
| LogP | 2.68-6.75 at 20℃ |
| CAS DataBase Reference | 6990-06-3(CAS DataBase Reference) |
| FDA UNII | 59XE10C19C |
| ATC code | D06AX01,D09AA02,J01XC01,S01AA13 |
Fusidine price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001411 | Fusidic acid European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | y0001411 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001394 | Fusidic acid for peak identification European Pharmacopoeia (EP) Reference Standard | 6990-06-3 | y0001394 | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2810 | Fusidic acid certified reference material, pharmaceutical secondary standard | 6990-06-3 | 50MG | $344 | 2024-03-01 | Buy |
| TCI Chemical | F1007 | Fusidic Acid >97.0%(HPLC)(T) | 6990-06-3 | 1g | $230 | 2024-03-01 | Buy |
| TCI Chemical | F1007 | Fusidic Acid >97.0%(HPLC)(T) | 6990-06-3 | 5g | $809 | 2024-03-01 | Buy |
Fusidine Chemical Properties,Uses,Production
Mode of action
Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.
Description
Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.
Chemical Properties
White Solid
Uses
Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.
Uses
antibacterial
Definition
ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
brand name
Fucidine (Bristol-Myers Squibb).
Hazard
Moderately toxic inhibitor of translocation during protein synthesis.
Biological Activity
Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.
Biochem/physiol Actions
Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.
Fusidine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 365)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2994 | 58 |
| Taizhou Creating Bio-pharm co., ltd. | +8613586099526 | post@creatingbiopharm.com | China | 217 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 467 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
Related articles
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- Sep 23，2024
- The steroid antibiotics---?Fusidic acid
- Fusidic acid was developed by Leo Laboratories in Copenhagen and obtained from the fungus Fusidium coccineum.
- Mar 18，2022
View Lastest Price from Fusidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | Fusidine
6990-06-3
|
US $0.00 / KG | 1KG | 97.5%-101%; EP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-22 | Fusidic Acid
6990-06-3
|
US $0.00 / Kg/Bag | 2Kg/Bag | 97.5% up / EP | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-11-22 | Fusidine,Fusidic acid
6990-06-3
|
US $0.00-0.00 / g | 10000g | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. |
-
- Fusidine
6990-06-3
- US $0.00 / KG
- 97.5%-101%; EP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fusidic Acid
6990-06-3
- US $0.00 / Kg/Bag
- 97.5% up / EP
- Sinoway Industrial co., ltd.
-
- Fusidine,Fusidic acid
6990-06-3
- US $0.00-0.00 / g
- 99.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
6990-06-3(Fusidine)Related Search:
Fusidic Acid Impurity J(EP)
16-Epidesacetylfusidic acid
Fusidic Acid Impurity B(EP)
Fusidic Acid Impurity E(EP)
(3α,4α,8α,9β,13α,14β,16β,17Z)-16-(Acetyloxy)-3-hydroxy-29-nordaMMara-17(20),24-dien-21-oic Acid
(8α,13α,14β,17Z)-16β-Acetoxy-3α-hydroxy-9,11-didehydro-29-nor-5α-dammara-17(20),24-dien-21-oic acid
11-monoketofusidic acid
26-Oxofusidic acid, Fusidic acid EP Impurity F
24,25-Dihydroxyfusidic Acid
Diethanolamine Fusidate
1of4
4-alpha,8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17z)-ph
ramycin
sq16603
Fusidic acid for peak identification
-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)
-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)
-6-methylhept-5-enoic acid
(3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid
Flucidin
Fucithalmic
NSC 56192
29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3.alpha.,4.alpha.,8.alpha.,9.beta.,11.alpha.,13.alpha.,14.beta.,16.beta.,17Z)-
16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
Fusidine
24-dien-21-oicacid,16-(acetyloxy)-3,11-dihydroxy-29-nordammara-17(20(3-al
FUSIDIC ACID IP
(4S,8α,9β,13α,14β,17Z)-16β-Acetoxy-3α,11α-dihydroxy-29-nor-5α-dammara-17(20),24-dien-21-oic acid
(8α,9β,13α,14β,Z)-16β-Acetyloxy-3α,11α-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid
Fuzidin
Fusidate Acid
Pyzidieb acid
(3a,4a,8a,9,11a,13a,147,167,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid
(3α,4α,8α,9β,11α,13α,147β,167β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordaMMara-17(20),24-dien-21-oic Acid
Fusidic acid, 98.5%
29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-
Fusidic acid for peak identification CRS
FusidicAcid>
Fusidine USP/EP/BP
Fusidine,Fusidic acid
Fusidic acid-D6Q: What is
Fusidic acid-D6 Q: What is the CAS Number of
Fusidic acid-D6 Q: What is the storage condition of
Fusidic acid-D6
Fusidic AcidQ: What is
Fusidic Acid Q: What is the CAS Number of
Fusidic Acid Q: What is the storage condition of
Fusidic Acid Q: What are the applications of
Fusidic Acid
(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID
FUSIDIC ACID
29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-
(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid
Fusidinic acid
Fusidic acid CRS
fusidicaci
Fusidie acid
Amlexanox Impurity 7
6990-06-3
3990-06-3
6990-6-3
C31H48O6
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