Neurokinin B | 86933-75-7

Neurokinin B Properties

RTECS	PC4360080
storage temp.	-20°C
solubility	Soluble to 1 mg/ml in DMSO
form	Lyophilized solid.
Water Solubility	Soluble to 0.80 mg/ml in sterile water
InChIKey	NHXYSAFTNPANFK-KWRJECPGNA-N

SAFETY

Risk and Safety Statements

WGK Germany	3

Neurokinin B price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N4143	Neurokinin B ≥95% (HPLC)	86933-75-7	0.5mg	$189	2024-03-01	Buy
Sigma-Aldrich	N4143	Neurokinin B ≥95% (HPLC)	86933-75-7	1mg	$263	2024-03-01	Buy
Alfa Aesar	J66607	Neurokinin B	86933-75-7	0.5mg	$81.9	2021-12-16	Buy
Alfa Aesar	J66607	Neurokinin B	86933-75-7	1mg	$107	2021-12-16	Buy
Sigma-Aldrich	N4143	Neurokinin B ≥95% (HPLC)	86933-75-7	5mg	$1110	2024-03-01	Buy

Product number	Packaging	Price	Buy
N4143	0.5mg	$189	Buy
N4143	1mg	$263	Buy
J66607	0.5mg	$81.9	Buy
J66607	1mg	$107	Buy
N4143	5mg	$1110	Buy

Neurokinin B Chemical Properties,Uses,Production

Structure

Tetrapod neurokinin B are composed of 10 amino acids. In several teleosts such as the zebrafish and salmon,NKBa consists of 10 amino acids, whereas NKBb, another zebrafish neurokinin B subtype, has 24 amino acids. NKF is composed of 13 aa. All tac3-derived peptides share the C-terminal Phe-X-Gly-Leu-Met-amide tachykinin (TK) sequence.In particular, NKBs and NKFs almost exclusively contain Val at the “X” position, as seeninNKA family peptides. Comparedwith NKA, NKB possesses no basic amino acid (Lys or Arg). These motifs and residues have been shown to play crucial roles in receptor activation and binding selectivity.

Gene, mRNA, and precursor

Neurokinin B is encoded in tac3 (or pptB). Vertebrate tac3 is organized by seven or eight exons. Most tetrapod NKB is present as a single copy in the fifth exon. To date, several splicing variants have been shown to be generated from tac3 in mammals while only NKB is produced from these precursors. In several teleosts including zebrafish and salmon, two tac3, tac3a and tac3b, are present. For instance, zebrafish tac3a encodes one 10-amino acid NKBa and one NKF, whereas one 24-aa NKBb and one additional NKF are encoded by tac3b, where only the second Asn of tac3a-derived NKF is replaced with Asp.

Receptors

TK receptors, namely NK1 (TACR1), NK2 (TACR2), and NK3 (TACR3), belong to the class A G protein-coupled receptor family. NKB displays selective affinity to NK3. In most teleosts, two subtypes, namely tac3ra and tac3rb, are conserved. NKF activated human NK3, and zebrafish TACR3a and TACR3b comparable to mammalian NKB or zebrafish NKBa, whereas zebrafish NKBb is 100- to 100-fold less potent than these NKB family peptides.
TK receptors

Signal transduction pathway

Mammalian and zebrafish NK3, expressed in Xenopus oocytes or cultured cells, triggers intracellular calcium mobilization and cAMP production in response to their selective ligands, followed by the activation of PKC, MAPK, and ERK phosphorylation in a cell- or tissuespecific manner.

Agonists and Antagonists

A number of mammalian NK3 agonists such as senktide and [MePhe7]neurokinin B are commercially available. A wide variety of NK3-competitive antagonists such as osanetant and talnetant are commercially available. It should be noted that almost no evidence has been provided for the pharmacological agonists or antagonists for mammalian NK3 on nonvertebrate homologs.

Biological functions

In mammals, NK3 is distributed in the brain, hypothalamus (including the median eminence), kidney, lung, placenta, prostate, testis, muscle, intestine, uterus, and the sperm midpiece as well as weakly in the proximal region of the sperm flagellum. In zebrafish, tacr3a is expressed mainly in the pituitary, also during embryonic development. A low tacr3b expression was detected in the midbrain and testis. In mammals, circulating NKB via the enhancement of expression of the tac3 gene was elevated in the placenta of preeclampsia women, but not in the placenta of women in normotensive pregnancy. Moreover, NKB participates in the regulation of GnRH pulse generation in the mammalian hypothalamus-pituitary-gonad axis. This GnRH release system is in part regulated by NKB in concert with kisspeptin yielded by KNDy neurons, whereas the involvement of non-KNDy NKB neurons or other kisspeptin-free NKB neurons in the stimulation of GnRH release is also reported. NK3R is also suggested to influence alcohol intake and behavioral/neurochemical responses to cocaine. In prepubertal zebrafish, estradiol treatment upregulates tac3a gene expression as well as kiss1, kiss2, and gnrh3. Furthermore, in sexually mature zebrafish, the intraperitoneal injection of NKBa and NKF resulted in the secretion of luteinizing hormone.

Clinical implications

NKB is highly likely to be involved in preeclampsia in the placenta and familial hypogonadotropic hypognadism.

Description

Vertebrate tachykinins encoded by TAC3 gene (Tac2 in rodents). In 1983, Kangawa et al. isolated neurokinin B (NKB) from the porcine spinal cord and elucidated the primary sequence as Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-amide, followed by the characterization of other tetrapod NKB. In 2012, teleost NKB and its-gene-related peptide, NKF, were identified.

Definition

ChEBI: Neurokinin B is a polypeptide. It is a mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family is similar in structure and action to substance P and neurokinin A. It has the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the urinary bladder and uterus.

Biochem/physiol Actions

Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.

storage

Store at -20°C

References

[1] LAUFERR. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1985, 82 21: 7444-7448. DOI:10.1073/pnas.82.21.7444.
[2] RANCENAOMI E. Neurokinin B and the hypothalamic regulation of reproduction.[J]. Brain Research, 2010, 1364: 116-128. DOI:10.1016/j.brainres.2010.08.059.
[3] MARIA ASMAT F. R M Ramzan. Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis[J]. International Journal of Peptide Research and Therapeutics, 2019, 26 1: 1259-1267. DOI:10.1007/s10989-019-09925-0.

Neurokinin B Preparation Products And Raw materials

Raw materials

Preparation Products

Neurokinin B Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10259	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	26267	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58

Supplier	Advantage
BOC Sciences	58
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
career henan chemical co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from Neurokinin B manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-06	NEUROKININ B 86933-75-7	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

NEUROKININ B
86933-75-7
US $1.00 / g
≥98%
Career Henan Chemical Co

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