Fisetin
- CAS No.
- 528-48-3
- Chemical Name:
- Fisetin
- Synonyms
- Fisetine;Fisetin Powder;2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chroMen-4-one;fisetholz;superfustel;Fisetin Extract;5-desoxyquercetin;ungarischesgelbholz;Cotinus coggygria extract;viset
- CBNumber:
- CB8451569
- Molecular Formula:
- C15H10O6
- Molecular Weight:
- 286.24
- MDL Number:
- MFCD00006829
- MOL File:
- 528-48-3.mol
- MSDS File:
- SDS
| Melting point | >330 °C(lit.) |
|---|---|
| Boiling point | 348.61°C (rough estimate) |
| Density | 1.2981 (rough estimate) |
| refractive index | 1.4413 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| Colour Index | 75620 |
| pka | 6.83±0.40(Predicted) |
| form | Solid |
| color | Pale Yellow to Very Dark Yellow |
| Merck | 14,4088 |
| BRN | 292829 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H |
| InChIKey | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC=C2C(=O)C=1O |
| LogP | 1.970 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | OO2ABO9578 |
| NCI Drug Dictionary | fisetin |
| EPA Substance Registry System | Fisetin (528-48-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LK9250000 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Fisetin price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82542 | Fisetin phyproof? Reference Substance | 528-48-3 | 20MG | $353 | 2023-06-20 | Buy |
| TCI Chemical | T0121 | Fisetin >96.0%(HPLC) | 528-48-3 | 100mg | $32 | 2024-03-01 | Buy |
| TCI Chemical | T0121 | Fisetin >96.0%(HPLC) | 528-48-3 | 1g | $135 | 2024-03-01 | Buy |
| Alfa Aesar | L14207 | 3,3',4',7-Tetrahydroxyflavone, 96% | 528-48-3 | 250mg | $62.65 | 2024-03-01 | Buy |
| Alfa Aesar | L14207 | 3,3',4',7-Tetrahydroxyflavone, 96% | 528-48-3 | 1g | $167.65 | 2024-03-01 | Buy |
Fisetin Chemical Properties,Uses,Production
Description
Fisetin, a well-known plant flavonol from natural flavonoid group, is found in traditional medicines, plants, vegetables, fruits. Fisetin also has anti-oxidant, anti-inflammatory, anti-tumor effects[1].
Chemical Properties
OCHRE POWDER
Uses
Fisetin is used in biological studies as spleen tyrosine kinase inhibitors for autoimmune inflammation disease. This compound has neuroprotective properties.
Definition
ChEBI: Fisetin is a 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antioxidant, an anti-inflammatory agent, a metabolite, a plant metabolite and a geroprotector. It is a 3'-hydroxyflavonoid, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a fisetin(1-).
Application
Fisetin is primarily used in laboratory bioactivity studies as an analytical standard for qualitative and quantitative analyses of Fisetin, and as a dietary supplement, and sells well for its potential anti-aging and cognitive enhancing effects. Because of its potent antioxidant and anti-inflammatory properties, it has been shown to have varying degrees of inhibitory effects on a wide range of diseases (e.g., cancer, Alzheimer's disease, anti-aging cells, and diabetes), and has been extensively studied in terms of its pharmacological effects in vitro and in vivo.
benefits
Fisetin is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection.It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Mechanism of action
Fisetin has multi-pathway and multi-target properties. Studies have shown that Fisetin can induce p53 activation and cause cell cycle arrest at various checkpoints by activating caspase-8, caspase-9, caspase-3 and inhibiting Bcl-2, leading to apoptosis, and inhibition of NF-κB and ERK1/2 activities, thus inhibiting the survival and growth of tumour cells. In addition, by inhibiting the PI3K/Akt pathway, it also blocks the mTOR pathway and controls feedback loops, as well as preventing oxidative stress, inflammatory responses, and cytotoxicity by modulating the activity of the PI3K/Akt, Nrf2, NF-κB, protein kinase C, and MAPK pathways.
Anticancer Research
Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).
Side effects
Fisetin is generally considered safe and no significant toxicity has been reported in humans when consumed in dietary amounts. However, as with any dietary supplement or medication, excessive intake of laccasein supplements may result in adverse reactions. Some of the potential adverse effects of laccasein supplementation may include gastrointestinal disturbances such as nausea, vomiting, and diarrhoea. In addition, fisetin may interact with certain medications, such as blood thinners, and may increase the risk of bleeding. fisetin may also have estrogenic activity, which means that it may interact with the body's endocrine system and affect individuals with hormone-sensitive diseases (e.g., breast cancer); therefore, it is important to take precautions before taking fisetin supplements, especially for individuals with a history of hormone-related medical conditions or who are taking medications that may interact with fisetin.
Source
Fisetin is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.
storage
Store at -20°C
References
[1] KIM T W. Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer.[J]. International Journal of Molecular Sciences, 2023, 24 10. DOI:10.3390/ijms24109076.
Fisetin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shangdong Yuanlitai Nutratech Co.,ltd | +8618782242822 | tatiana@yltnutra.com | China | 8 | 58 |
| XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD | 15202951039 | jason@sgonekbio.com | China | 268 | 58 |
| ZhenYiBio Technology Inc | +8615309206328 | alexxue@zhenyibio.com | China | 298 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5868 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 987 | 58 |
| Shanghai EGT Synbio Group Co., Ltd. | +86-021-60410486 +8618621797362 | yg@ygingredients.com | China | 7 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3005 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 307 | 58 |
Related articles
- Function and mechanism of action of Fisetin in cancer
- Fisetin has been shown to inhibit invasion and migration of various types of cancer cells.
- Mar 24，2025
- The Source and Biological Activity of Fisetin
- Fisetin is a dietary flavonoid found in various fruits (strawberries, apples, persimmons, mangoes, kiwis, and grapes), vegetab....
- Dec 19，2023
View Lastest Price from Fisetin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Fisetin
528-48-3
|
US $0.00 / kg | 1kg | 98%HPLC | 1 ton | Hovane Phytochemicals Co., Ltd | |
 |
2025-04-27 | Fisetin
528-48-3
|
US $0.00 / kg | 1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2025-04-27 | Fisetin
528-48-3
|
US $0.00-0.00 / kg | 20kg | 99% | 200000 | Wuhan Haorong Biotechnology Co.,Ltd |