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RU-302

RU-302 structure

CAS No.: 1182129-77-6

Chemical Name:: RU-302

Synonyms: RU-302;Methanone, [2-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]phenyl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-

CBNumber:: CB84668468

Molecular Formula:: C24H24F3N3O2S

Molecular Weight:: 475.53

MDL Number:: MFCD15344345

MOL File:: 1182129-77-6.mol

Last updated:2024-07-02 08:55:36

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RU-302 Properties

Boiling point	624.0±55.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (210.29 mM; Need ultrasonic)
form	Solid
pka	1.52±0.20(Predicted)
color	White to off-white

RU-302 Chemical Properties,Uses,Production

Biological Activity

RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].

References

[1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908.

RU-302 Preparation Products And Raw materials

Raw materials

Preparation Products

RU-302 Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3466	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7887	56
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58
Shanghai Dongyang Biotechnology Co., Ltd.	0512-0512-13601744364 13601744364	chemsharker@126.com	China	896	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5587	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29978	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9268	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Shanghai Chaolan Chemical Technology Center	58
Shanghai Dongyang Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Nanjing Tengyi Biotechnology Co., Ltd	58
https://hanhongsci.com/	58
RD International Technology Co., Limited	58

RU-302 Methanone, [2-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]phenyl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]- 1182129-77-6